养心颗粒对冠状动脉粥样硬化性心脏病患者心功能指标的影响

Effect of Yangxin Granule on Cardiac Function Index in Patients with Coronary Arteriosclerotic Heart Disease

目的:观察养心颗粒对冠状动脉粥样硬化性心脏病(冠心病)患者心功能指标的影响。方法:71例冠心病患者按随机数字表法分为对照组34例和观察组37例,对照组口服口服银丹心脑通软胶囊,观察组在常规治疗基础上加用养心颗粒。观察治疗前后左室射血分数(EF)、心排血量(CO)、心脏排血指数(CI);左室壁运动状态计分;超声心动图测量LVDs、LVDd、LVESV、LVEDV;NYHA分级。结果:治疗后,EF、CO、CI与治疗前比较明显增加(P<0.05);观察组优于对照组,两组比较,差异有统计学意义(P<0.01)。治疗后两组患者左室壁运动计分较治疗前明显降低(P<0.05);观察组优于对照组(P<0.05)。两组患者在治疗前后超声心动图对比有显著性差异(P<0.05);但两组患者在治疗后比较,差异无统计学意义(P>0.05);观察组治疗后可提高NYHA心功能分级。结论:养心颗粒改善冠心病患者心功能指标效果显著,且具有较高的安全性和可靠性。

Objective ：To study the effect of Yangxin Granule on caMiac function index in patients with coronary arteriosclerotic heart disease. Methods ： 71 cases of patients with coronary arteriosclerotic heart disease were randomly divided into the control grnup of 34 ea- ses and the observation group of 37 cases. The control group was given oral Yindan Xinnaotong Soft Capsule, the observation group on the basis of conventional therapy plus Yangxin Granule. Left ventricular ejection fraction （EF） , cardiac output （ CO ） , cardiac index （CI） ; left ventricular wall motion state score; LVDs, LVDd, LVESV, LVEDV measured by ultrasonic heartbeat maps, NYHA classifica- tion before and after treatment were observed. Resuhs：After treatment,left ventricular ejection fraction （ EF）, cardiac output （ CO）, car- diac index （CI） were increased significantly compared to before treatment（ P 〈0.05 ）; comparison of the observation group and the control group showed that the difference was statistically significant （P 〈 0.01 ） ;after treatment, left ventricular wall motion scores of patients were significantly lower than that before treatment （ P 〈 0.05 ） ; and that in the observation group were superior than the control group（ P 〈 0.05 ） ;comparison ultrasonic cardiogram in patients of two groups before and after treatment has significant difference （P 〈 0.05 ） ; but compared with the two groups after treatment, there was no statistical significance （ P 〉 0.05 ） ; the observation group after treatment can improve cardiac function grade of NYHA. Conclusion：Yangxin Granule has significant improvement on cardiac function indexes in coronary arteriosclerotic heart disease patients, with high safety and reliability.