急性脑梗死患者血小板参数、D-二聚体及脂蛋白a的变化及其临床意义

Study on changes and clinical significance of platelet parameters,D-dimer and lipoprotein a in patients with acute cerebral infarction

目的探讨血小板计数(PLT)、血小板分布宽度(PDW)、血小板平均体积(MPV)、血小板比容(PCT)、网织血小板比率(IPF)、D-二聚体(D-D)和脂蛋白a(Lp-a)与急性脑梗死的关系。方法对231例急性脑梗死患者(急性脑梗死组)PLT、PDW、MPV、PCT、IPF、血浆D-D和血清Lp-a进行检测及分析,选择健康人群50名作为对照组。结果与对照组比较,急性脑梗死组PLT、PCT明显减少(P<0.01);PDW、MPV、IPF、D-D和Lp-a明显升高(P<0.01)。结论血小板参数、D-D和Lp-a水平的变化与急性脑梗死的发生发展密切相关,监测它们的变化对预防和治疗急性脑梗死具有重要的临床意义。

Objective To investigate the relationship between platelet count （PLT）, platelet distribution width （PDW, mean platelet volume（MPV）, platelet hematocrit （PCT）, reticulated platelet ratio （IPF）, D-dimer （D-D） and lipoprotein a （Lp-a） and pa- tients with acute cerebral infarction. Methods 231 cases of patients acute cerebral infarction （acute cerebral infarction group） were detected for PLT,PDW,MPV,PCT,IPF,D-D and Lp-a,50 cases of healthy people were selected as control group. Results Com- pared with control group,PLT and PCT in acute cerebral infarction group were obviously lower （P〈0.01） ;PDW,MPV,IPF,D-D and Lp-a were obviously higher （P〈0.01）. Conclusion There are closely relationship between changes of platelet parameters,D-D and Lp-a variation with the occurrence of acute cerebral infarction,monitoring the levels change of them to prevention and treat a- cute cerebral infarction,which have important clinical significance.