黄果茄植物提取物对鱼类和大鼠急性毒性试验的观察

Observation on Acute Toxicity Test to Fish and Mouse with the Extraction of Solanum xanthocarpum

为掌握和了解黄果茄植物提取物对鱼类和大鼠的急性毒性 ,本研究进行了常规的鱼类急性毒性试验和大鼠急性经口毒性试验。结果表明 ,黄果茄植物提取物对鱼类稀有鱼句鲫的急性毒性试验 ,在 0 .2 70 mg/ L浓度中 ,2 4h稀有鱼句鲫死亡率为 0 % ;在 17.2 8mg/ L中 ,2 4h稀有鱼句鲫死亡率为 10 0 % ;SX对稀有鱼句鲫 2 4h L C5 0 为 2 .0 2 mg/ L ,95 %的可信限为 1.33～ 3.0 6 mg/ L。对大鼠急性经口毒性的绝对致死剂量为 2 15 0 mg/ kg· bw,L D5 0 为 794mg/ kg· bw,95 %可信限为 5 84～10 80 mg/ kg· bw,属低毒类。

To understand acute toxicity related to the extraction of Solanum xanthocarpum to fish and mouse (Solanum xanthocarpum is called SX for short form as below), the normal tests of acute toxicity to fish and mouse were carried out at the laboratory. The result showed that the rare minnow mortality was zero under the concentration of 0.270mg/L for 24 hours, and 100% under the concentration of 17.28mg/L for 24 hours. LC 50 of SX to rare minnow was 2.02mg/L for 24 hours, and the confidence limits 95% was 1.33～3.06mg/L. The acute toxicity on absolute lethal dose of SX to mouse was 2 150mg/kg·bw by mouth, LD 50 of SX to mouse was 794mg/kg·bw, and the confidence limits 95% was 584～1 080 mg/kg·bw. That indicated SX belonging to middle toxicity material to rare minnow and low toxicity material to mouse.