增城市荔城农村老年高尿酸血症现况及危险因素分析

Prevalence survey and risk factors of hyperuricemia for rural elderly people of Licheng Street in Zengcheng City

目的探讨增城市荔城农村老年高尿酸血症流行现状及相关危险因素,探索社区综合防治措施。方法采用分阶段系统随机抽样,抽取荔城街农村60岁以上老人1036名,进行问卷调查、常规体检(包括血压、身高、体重、腰围、臀围)及实验室检测(包括血尿酸、血糖、血脂、肝功能、肾功能等)。统计不同年龄组、不同性别人群慢性病患病率。调查时间为2013年1~6月。根据血尿酸结果进行分组,结果大于标准值的作为高尿酸血症组,另外在血尿酸结果正常人群中随机抽取等量的人群作为正常组。结果老年人高尿酸血症患病率达18.3%(190/1036),其中,男患病率为22.5%(86/383);女患病率为15.9%(104/653)。与正常组比较,高尿酸血症组低密度脂蛋白胆固醇(LDL-C)水平升高(P<0.05),血肌酐(Cr)、血尿素氮(BUN)水平明显升高(P<0.01)。非条件Logistic回归分析结果显示,肾功能不全(OR=9.746,95%CI:4.911~19.342)、血脂异常(OR=5.281,95%CI:3.277~8.513)、吸烟(OR=2.035,95%CI:0.989~4.191)、高血压(OR=1.810,95%CI:1.197~2.736)、超重肥胖(OR=1.572,95%CI:1.103~2.239)及性别(OR=0.661,95%CI:0.456~0.959)均与高尿酸血症相关。结论增城市荔城农村老年人高尿酸血症患病率较广州其他地区低,影响因素可能包括肾功能不全、血脂异常、吸烟、高血压、超重肥胖及性别等。

Objective To survey and analyze the hyperuricemia prevalence of rural elderly people and related risk fac- tors, and explore community comprehensive prevention and control measures in Licheng Street of Zengcheng City. Methods Systematic random sampling was used, 1036 residents aged over 60 were selected to conduct questionnaire survey, routine checkups （including blood pressure, height, weight, waist, hip） and laboratory tests （including blood uric acid, glucose, lipids, liver function, kidney function, etc）. Statistics for prevalence of chronic diseases of different age groups, different gender groups. The survey was conducted from January to June 2013. According to the results of blood uric acid, residents with blood uric acid higher than standard values were divided into the hyperuricemia group, while, randomly selected the same amount of people with normal blood uric acid level as the control group. Results The hy- peruricemia prevalence in total was 18.3% （190/1036）, which in female and male were 15.9% （104/653） and 22.5% （86/383） respectively. Compared with the normal group, LDL-C level of hyperuricemia group increased （P 〈 0.05）, serum creatinine （Cr）, blood urea nitrogen （BUN） levels significantly increased （P 〈 0.01）. Unconditioned Logistic re- gression analysis showed that renal insufficiency （OR=9.746, 95%CI： 4.911-19.342）, dyslipidemia （OR=5.281, 95%CI： 3.277-8.513）, smoking （OR=2.035, 95%CI： 0.989-4.191）, hypertension （OR=l.810, 95%CI： 1.197-2.736）, overweight and obesity （OR=1.572, 95%CI： 1.103-2.239） and gender （OR=0.661, 95%CI： 0.456-0.959） were associated with hy- peruricemia. Conclusion The hyperuricemia prevalence rate of rural senile in Licheng Street of Zengcheng City is sig- nificantly lower than other parts of Guan^zhou City. Factors mac include renal insufficiency, dvslioidemia, smokinz.high blood pressure, overweight, obesity and gender.