佛山市顺德区成人非酒精性脂肪性肝病的现状研究

Research of present situation of adult nonalcoholic fatty liver disease in Shunde District of Foshan City

目的调查佛山市顺德区成人非酒精性脂肪性肝病的现状。方法收集佛山市顺德区陈村医院普通体检者1673名相关临床资料，包括身高、体重、腰围、血压、肝功能、血脂、血糖及肝脏、胆囊和脾脏超声检查等，进行统计学分析，探讨佛山市顺德区成人非酒精性脂肪肝性肝病的现状和疾病谱以及相关危险因素。结果1673名普通体检者中检出非酒精性脂肪性肝病患者258例，检出率为15．4％，其中男性患病率为17．5％。女性患病率为12．4％，男性患病率明显高于女性；非酒精性脂肪性肝病高发年龄段为40～〈60岁；非酒精性脂肪性肝病发病相关因素包括体重指数、高脂血症、性别、年龄、肝功能异常、空腹血糖代谢紊乱、高血压，其中，以体重指数≥25kg/㎡相对风险度最高（OR=9．942，95％CI4．802～20．576），其次为高脂血症（OR=2．062，95％CI1．285～3．311）及男性（OR=1．810，95％CI1．150～2．811）。结论佛山市顺德区成人非酒精性脂肪性肝病患病率较高，与国内发达城市相差不大，在40～〈60岁人群及男性中较高发，肥胖、高脂血症为非酒精性脂肪性肝病的易患因素；应积极开展关于非酒精性脂肪性肝病防治的健康教育，引起人们对非酒精性脂肪性肝病的重视，加强自我保健意识。

Objective To investigate the present situation of adult nonalcoholic fatty liver disease in Shunde District of Foshan City. Methods Clinical data of 1673 cases with physical examination in Chen Village Hospital of Shunde Dis- trict in Foshan City were selected. Height, weight, waist circumference, blood pressure, liver function, blood lipids, blood glucose, ultrasound examination of liver, gallbladder and spleen were included, and the data were analyzed, in or- der to discuss the the present situation of adult nonalcoholic fatty liver disease in Shunde District of Foshan City and its related risk factor. Results There were 258 patients with nonalcoholic fatty liver disease among 1673 cases, the preva- lence rate was 15.4%, 17.5% in male, 12.4% in female, the prevalence rate in male was higher than female. The peak ages of nonalcoholic fatty liver disease was 40-〈60. BMI, hyperliperaia, gender, age, liver function abnormalities, FBG metabolic disorders, high blood pressure were associated with nonalcoholic fatty liver disease, in which BMI ≥ 25 kg/m 2 had highest degree of risk （OR=9.942, 95%C1 4.802-20.576）, followed by hyperlipemia （OR=2.062, 95%CI 1.285-3.311） and male （OR=l.810, 95%CI 1.150-2.811）. Conclusion The prevalence of adult nonalcoholic fatty liver disease in Shunde District of Foshan City is high, which has small different with domestic developed cities, and has occurred fre- quently in male aged 40-〈60. Obesity and hyperlipidemia are the risk factors of adult nonalcoholic fatty liver disease. Health education for prevention of adult nonalcoholic fatty liver disease should be actively developed, and cause peo- ple＇s emphasis on nonalcoholic fatty liver disease, in order to strengthen self health care consciousness.