摘要
近年来儿童恶性肿瘤发病率明显上升,已成为儿童疾病主要死亡原因之一。神经母细胞瘤(neuroblastoma,NB)是常见的儿童颅外恶性肿瘤,在儿童所有肿瘤相关死亡原因中达15%。NB临床特点为原发部位隐匿,早期无特异性症状,早期诊断困难,恶性程度高,发展迅速且易发生早期转移等。NB肿瘤起源于神经嵴组织,常发生于肾上腺髓质或脊柱旁神经节,常表现为颈部、胸部、腹部和骨盆部的肿块,原发瘤最多见的部位为腹膜后和后纵隔。
出处
《中国小儿血液与肿瘤杂志》
CAS
2014年第2期65-68,共4页
Journal of China Pediatric Blood and Cancer
参考文献42
-
1Capasso M, Diskin SJ. Genetics and genomics of neuroblastoma. Cancer Treat Res, 2010, 155: 65-84.
-
2张健,董亮,崔华雷.神经母细胞瘤相关基因的研究进展[J].临床小儿外科杂志,2006,5(6):443-446. 被引量:2
-
3Maris JM. Recent Advances in Neuroblastoma. N Engl J Med, 2010, 362: 2202-2211.
-
4黄永富,曹兴建,刘春霞.神经母细胞瘤细胞学研究进展.临床检验志,2007,04:313-316.
-
5金眉,张大伟,王焕民,秦红,周春菊,马晓莉.儿童腹膜后神经母细胞瘤56例临床分析[J].中国循证儿科杂志,2012,7(3):196-199. 被引量:12
-
6张大伟,金眉,曾骐,周春菊,马晓莉.后纵隔神经母细胞瘤35例[J].实用儿科临床杂志,2012,27(11):835-836. 被引量:8
-
7Maris JM, Hogarty MD, Bagatell R, et al. Neuroblastoma. Lancet, 2007, 369(9579) : 2106-2120.
-
8Knudson AG Jr, Strong LC. Mutation and cancer: neuroblastoma and pheochromocytoma. Am J Hum Genet, 1972, 24 : 514-532.
-
9Cheung NK, Dyer MA. Neurohlastoma: developmental biology, cancer genomics and immunotherapy. Nat Rev Cancer, 2013, 13: 397-411.
-
10Moss YP, Laudenslager M, Khazi D, et al. Germline PHOX2B mutation in hereditary neuroblastoma. Am J Hum Genet, 2004, 75 : 727-730.
二级参考文献83
-
1[1]Vasudevan SA,Nuchtern JG and Shohet JM.Gene profiling of high neuroblastoma[J].World J Surg,2005,29:317-324.
-
2[2]Spix C,Pastore G,Sankiia R,et al.Neuroblastoma incidence and survival in European children (1978-1997):Report from the Automated Childhood Cancer Information System project[J].Eur J Cancer,2006,42:2081-2091.
-
3[3]Tanaka T,Iehara T,Sugimoto T,et al.Diversity in Neuroblastomas and discrimination of the risk to progress[J].Cancer Lett,2005,228:267-270.
-
4[4]Pitts EV,Potluri S,Hess DM,et al.Neurotrophin and Trk-mediated signaling in the neuromuscular system[J].Int Anesthesiol Clin,2006,44:21-76.
-
5[5]Schramm A,Schulte JH,Astrahantseff K,et al.Biological effects of Trk A and Trk B receptor signaling in neuroblastoma[J].Cancer Lett,2005,228:143-153.
-
6[6]Klein R,Nanduri V,Jing SA,et al.The Trk proto-oncogene product a signal transducing receptor for nerve growth factor[J].Science,1991,252:554-558.
-
7[7]Klein R,Nanduri V,Jing SA,et al.The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3[J].Cell,1991,66:395-403.
-
8[8]Klein R,Lamballe F,Bryant S,et al.The trkB tyrosine protein kinas is a receptor for neurotrophin-4[J].Neuron,1992,8:947-956.
-
9[9]Gentry JJ,Barker PA and Carter BD.The p75 neurotrophin receptor:multiple interactors and numerous functions[J].Prog Brain Res,2004,146:25-39.
-
10[10]Casaccia-Bonnefil P,Gu C,Chao MV.Neurotrophins in cell survival/death decisions[J].Adv Exp Med Biol,1999,468:275-282.
共引文献27
-
1杨少波(综述),肖现民(审校).神经母细胞瘤分子遗传学研究进展[J].临床小儿外科杂志,2010,9(6):453-456. 被引量:2
-
2杨春兰,岳丽杰,江贤萍,文飞球,郑苗苗.儿童神经母细胞瘤中ALK基因突变的研究[J].中国当代儿科杂志,2012,14(10):763-766.
-
3岑龙,吴江.神经母细胞瘤的诊治新进展[J].广东医学,2013,34(2):327-330. 被引量:5
-
4陈超,罗意革,董淳强,刘强,董昆,苏成,杨体泉.广西小儿恶性实体瘤发病特点及诊断治疗[J].中华实用儿科临床杂志,2013,28(23):1805-1807. 被引量:5
-
5陈哲,许崇永,吴海,相世峰,邱乾德.儿童纵膈神经母细胞瘤CT特征[J].中华内分泌外科杂志,2013,7(6):498-501. 被引量:1
-
6朱小鹏,徐炎华.EML4-ALK融合基因在非小细胞肺癌中的研究[J].临床肺科杂志,2014,19(1):133-136.
-
7徐玲玲,唐雯,李素萍,刘钧澄,梁玉坚,张丽丹,兰洁.婴儿后纵隔神经母细胞瘤1例[J].中华实用儿科临床杂志,2014,29(3):237-238. 被引量:1
-
8刘菁华,朱珍,张骥,史青.儿童腹膜后神经母细胞瘤CT特征分析[J].国际医学放射学杂志,2014,37(2):106-109. 被引量:9
-
9潘慈,张安安,叶启东,周敏,薛惠良,陈静,罗长缨,沈树红,王坚敏,汤燕静,汤静燕.儿童1、2期神经母细胞瘤临床研究[J].临床儿科杂志,2014,32(5):410-412. 被引量:4
-
10林钱森,陈自谦,吴清清.腹膜后神经源性肿瘤的分类及多模态影像学分析[J].功能与分子医学影像学(电子版),2013,2(3):33-37. 被引量:3
同被引文献9
-
1Bown N.Neuroblastoma tumor genetics:clinical and biological aspects[J].J Clin Pathol,2001,54(12):897-910.
-
2Brodeur GM,Nakagawara A.Molecular basis of clinical heterogeneity in neuroblastoma[J].Am J Pediatr Hematol Oncol,1992,14(2):111-116.
-
3Brodeur GM.Neuroblastoma:biological insights into a clinical enigma[J].Nat Rev Cancer,2003,3(3):203-216.
-
4Pizzo PA,Poplack DG.Principles and practice of pediatric oncology[M].Fourth Edition.Philadelphia:Lippincott-Raven,2001:895-937.
-
5Kaneko Y,Suenaqa Y,Islam SM,et al.Functional interplay between MYCN,NCYM and OCT4 promotes aggressiveness of human neuroblastomas[J].Cancer Sci,2015:12677.
-
6London WB,Castel V,Monclair T,et al Clinical and biological features predictive of survival after relapse of neuroblastoma:a report from the International Neuroblastoma Risk Group Project[J].J Clin Oncol,2011,29(24):3286-3292.
-
7Takahashi K,Tanabe K,Ohnuki M,et al.Induction of pluripotent stem cells from adult human fibroblasts by defined factors[J].Cell,2007,131(5):861-872.
-
8Yu J,Vodyanik MA,Smuga-Otto K,et al.Induced pluripotent stem cell lines derived from human somatic cells[J].Science,2007,318(5858):1917-1920.
-
9Kaneko Y,suenaqa Y,Islam SM,et al.Functional interplay between MYCN,NCYM and OCT4 promotes aggressiveness of human neuroblastomas[J].Cancer Sci,2015,16.
-
1任涛,谭榜完,柳弥.95例肺癌脑转移放射治疗疗效分析[J].国际肿瘤学杂志,2010,37(3):237-238.
-
2侯永宏,刘运生,唐建兵,仇斌,马志明湖南医科大学附属湘雅医院神经外科.侵袭前中颅窝底颅外恶性肿瘤的伽玛刀治疗[J].中国耳鼻咽喉颅底外科杂志,1997,3(4):214-217.
-
3袁婕,王捷忠.非小细胞肺癌脑转移放射治疗进展[J].福建医科大学学报,2015,49(1):62-66. 被引量:6
-
4祝秀丹.儿童肿瘤治疗现状[J].中国处方药,2005,4(2):24-28. 被引量:7
-
5秦坤明.颅外恶性肿瘤并发脑出血2例报告[J].右江民族医学院学报,2002,24(2):284-284.
-
6陈小华,李桂香.脑转移瘤放射治疗进展[J].西北国防医学杂志,2014,35(1):52-54. 被引量:1
-
7黄程,马晓莉.神经母细胞瘤生物学特征及其预后因素的研究进展[J].中华实用儿科临床杂志,2016,31(3):235-237. 被引量:13
-
8韩璐.儿童白血病的早期症状[J].大家健康,2011(12):77-77.
-
9周大彪.Epidemiology of nervous system tumors in children: a survey based on 1267 consecutive cases[J].China Medical Abstracts,2007,16(2):125-125.
-
10张红梅.颅脑转移瘤的MRI诊断与鉴别诊断[J].中国临床医生杂志,2014,42(4):2-5. 被引量:8