多囊卵巢综合征致不孕患者的相关因素分析

Relative factors analysis of polycystic ovarian syndrome in infertile women

目的 探讨多囊卵巢综合征（PCOS）致不孕患者的相关因素.方法 选择2008年1月至2012年12月因不孕症来我院就诊确诊为PCOS患者98例（PCOS组）,在同期因不孕症就诊、无PCOS表现且腹腔镜检查卵巢组织结构正常的患者中随机选取280例作为对照组,回顾性分析两组患者的一般资料、生育相关因素、腹腔镜探查情况.结果 PCOS组初潮年龄在13岁以下者51例（52.0％）,对照组113例（40.4％）,组间比较差异有统计学意义（x2=4.03,P＜0.05）;PCOS组月经不规律11例（11.2％）,对照组12例（4.3％）,组间比较差异有统计学意义（x2 =6.12,P＜0.05）;PCOS组盆腔粘连60例（21.1％）,对照组224例（40.4％）,组间比较差异有统计学意义（x2 =13.70,P＜0.05）.月经不规律是不孕女性PCOS发生的危险因素（OR=1.770,95％ CI为1.09～2.88,P=0.002）.结论 临床应加强对青春期月经初潮提前及月经不规律且有PCOS相关症状人群的关注,早期筛查、早期发现,早期预防、早期治疗,从而降低PCOS致不孕的发生率,降低远期并发症.

Objective To explore the relative factors of polycystic ovarian syndrome （PCOS） in infertile women.Methods Ninety-eight infertile women diagnosed PCOS at affiliated hospital of the Chinese People＇s Armed Force Logistic college from Jan.2008 to Dec.2012 were served as PCOS group.Two hundred and eighty infertile women with normal ovarian structure according to laparoscopic examination result were selected as control group.The general information,factors related infertile and laparoscopic examination of the two groups were recorded.Results Fifty-one cases （52.0%） in PCOS group were with menarche age earlier than 13 years old,higher than that of control group （113 （40.4%）,x2 =4.03,P 〈 0.05）.Eleven cases （11.2%） in PCOS group were with abnormal menstruation cycle,higher than that of control group （12 （4.3%）,x2 =6.12,P 〈 0.05）.The incidence of pelvic adhesions in PCOS group was lower than the control group（60（21.1%） vs.224（40.4%）,x2 =13.70,P 〈0.05）.Irregular menstruation cycle was risk factor of PCOS （OR=1.770,95% CI：1.09-2.88,P =0.002）.Conclusion Women with earlier menarche and irregular menstruation cycle should be paid more attention in terms of PCOS,early screening,discovery,prevention and treatment,so as to reduce the incidence of PCOS induced infertility and the long-term complications.