血清胆红素水平与AECOPD关系的临床研究

Clinical analysis on changes in the serum bllirubin with chronic obstructive pulmonary disease during acute exacerbation periods(AECOPD)

目的:探讨胆红索(BIL)水平在慢性阻塞性肺疾病急性加重期(AECOPD)患者血清中的表达的变化及临床意义。方法:106例AECOPD患者作为AECOPD组,74例慢性阻塞性肺疾病稳定期患者作为稳定组,63例健康体检者作为对照组,采用全自动生化仪检测所有入选人群的血清总胆红素(TBIL)、直接胆红索(DBIL),并计算间接胆红素(IBIL)水平;测定肺功能和动脉血气分析。结果:AECOPD组和稳定组血清TBIL、DBIL、IBIL均明显低于对照组,AECOPD组血清TBIL、DBIL、IBIL较稳定组明显降低;AECOPD组和稳定组患者FEV1%、FEV1/FVC%较对照组明显降低,AECOPD组FEV1%、FEV1/FVC%较稳定组明显降低;AECOPD组和稳定组血气分析PCO2较对照组明显升高,PO2和SaO2较对照组明显降低,AECOPD组PCO2较稳定组明显升高,PO2和SaO2较稳定组明显降低,差异均有统计学意义(P<0.05)。结论:AECOPD生理范围的血清BIL水平轻度升高变化有可能防止AECOPD病情进展。

Objective：To study the changes of serum bilirubin （BIL） levels and its clinical significance on pa- tients with chronic obstructive pulmonary disease during acute exacerbation periods. Method： Serum Bllirubin Lev- els,arterial blood gas analysis and pulmonary function parameters were collected and analyzed on 106 the patients with chronic obstructive pulmonary disease during acute exacerbation periods. 74 chronic obstructive pulmonary disease and 63 healthy volunteers were measured respectively. Spearman rank correlation was used for correlation analysis. Result：The serum levels of bilirubin in AECOPD group was significantly lower than that in the control group（P〈0.05）. The FEVI% ,FEV1/FVC%in AECOPD group was significantly lower than that in the control group and stable group;The PCO2 of AECOPD group was significantly higher than the control group and stable group;POe and SaO2 were significantly lower than the control group and stable group. Conclusion.. The higher ser- um concentration of bilirubin in physiological range may prevent AECOPD disease.