健脾散结丸对胃肠功能影响的实验研究

Effects of Jianpisanjie Pills on the Gastro-Intestinal Functions

目的观察健脾散结丸对实验动物胃肠功能的影响。方法采用硫酸阿托品造成小鼠胃排空和小肠推进障碍,利用硫酸铜致家鸽呕吐,观察健脾散结丸对胃肠障碍模型动物胃肠运动,以及家鸽呕吐潜伏期和呕吐次数的影响。建立肝癌H22荷瘤小鼠模型并给予化疗药物,称重后随机分为模型组、健脾散结丸组(高、中、低剂量组)、越鞠保和丸阳性对照组,给药后测定各组体重和进食量,观察健脾散结丸对肿瘤化疗产生体重减轻和进食量减少的毒副反应的影响。结果健脾散结丸不同剂量组可显著提高小鼠胃酚红排空率、胃肠炭末推进率,延长硫酸铜所致家鸽呕吐潜伏期,减少呕吐次数。不同剂量健脾散结丸与化疗药联合应用后对肿瘤化疗产生的体重减轻、进食量减少毒副反应有不同程度的改善作用。结论健脾散结丸可促进胃肠功能,对肿瘤化疗进食量少和体重低下有明显的改善作用,可作为辅助药物用于肿瘤治疗。

OBJECTIVE To investigate the effects of Jianpisanjie（JPSJ） pills on the gastro-intestinal functions by animal experi- ment. METHODS With gastric evacuation and gastrointestinal propulsion movement of mice obstructed by atropine sulphate, and the emesis of pigeon resulted by copper sulfate, the effects of JPSJ on gastrointestinal function was investigated, the effects on vomit latent period and emesis times were also studied. The model of hepatoma H22 bearing mice was established. After weighting, the mice were randomized into 5 groups, they were the control group, the high, middle, low dosages of JPSJ, and the positive-control group. Then they were treated with chemotherapy and administrated with subject drugs. When the trial ended, the weight and food intake of H22 bearing tumor were determined. RESULTS Different dosage of JPSJ could increase the gastric evacuation rate and gastrointestinal propulsion rate, prolong the vomit latent period and emesis times of pigeon. And the pills also could reduce the side-effects of chemo- therapy, such as weight of mice and food intake. CONCLUSION JPSJ could promote the gastro-intestinal function, improve the weight loss and less food intake resulted by chemotherapy, and may be adjuvant drug for tumor.