摘要
目的确定阿司匹林软膏剂的最佳处方。方法以6 h累积渗透量和皮肤刺激性为考察指标,选择阿司匹林软膏处方中对指标影响较显著的3个因素:十二烷基硫酸钠、枸橼酸三钠、三乙醇胺为考察对象,采用中心组合设计法对阿司匹林软膏处方进行优化。结果阿司匹林软膏的最佳处方是:十二烷基硫酸钠1.41%,枸橼酸三钠3.50%,三乙醇胺3.00%。按照优化处方制备了3批阿司匹林软膏样品,其6 h平均累积渗透量为990.18μg·cm-2,产品无明显刺激性。结论中心组合设计法应用简便、预测性好,制备的阿司匹林软膏符合设计要求。
OBJECTIVE To optimize the formulation of aspirin ointment. METHODS With cumulative permeation quantity within 6 h and shin irritation as indexes, the method of central composite design was used to optimize the formulation of aspirin oint- ment, taking the most important three ingredients including sodium lauryl sulfate( X1 ), sodium citrate (X2 )and triethanolamine( X3 ) as the study subjects. RESULTS The optimized formulation of aspirin ointment was composed of 1.41% sodium lauryl sulfate, 3.5% sodium citrate and 3.0% triethanolamine. Three batches of aspirin ointment were prepared using the optimized formulation, for which the average cumulative permeation quantity within 6 h was 990. 18 μg.cm -2, and no obvious shin irritation was observed. CONCLUSION Central composite design is successfully used to optimize the formulation of aspirin ointment.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2014年第7期578-582,共5页
Chinese Pharmaceutical Journal
基金
国家自然科学基金资助项目(81202479)
教育部重点项目(212148)
泸州医学院重点项目
关键词
阿司匹林软膏
中心组合设计法
处方优化
aspirin ointment
central composite design
prescription optimization