C型利钠肽水平与心房颤动不同类型关系的临床研究

Clinic study on relationship between C-type natriuretic peptide level and various types of atrial fibrillation

目的探讨血浆C型利钠肽(CNP)水平变化与心房颤动不同类型的关系。方法将2012年10月至2013年10月该院门诊或住院治疗的心房颤动患者135例作为心房颤动组,其中永久性心房颤动组45例,持续性心房颤动组43例,阵发性心房颤动组47例;另选择健康体检者40例作为对照组。采用酶联免疫吸附试验方法检测血浆CNP水平,采用超声心动图测量心脏结构。结果各心房颤动组患者血浆CNP水平[阵发性心房颤动组为(26.46±9.32)pg/mL、持续性心房颤动组为(30.98±12.20)pg/mL、永久性心房颤动组为(70.62±20.30)pg/mL]明显高于对照组[(15.25±5.48)pg/mL],差异均有统计学意义(P<0.05);永久性心房颤动组患者血浆CNP水平明显高于持续性心房颤动和阵发性心房颤动组,差异均有统计学意义(P<0.05)。结论心房颤动患者血浆CNP水平升高,且永久性心房颤动患者血浆CNP水平高于持续性心房颤动和阵发性心房颤动患者。

Objective To explore relationship between changes of plasma C-type natriuretic peptide（CNP）level and var-ious types of atrial fibrillation（AF）. Methods The 135 atrial fibrillation out-patients or in-patients from October 2012 to October 2013 were divided into three groups：45 patients with permanent atrial fibrillation ,43 patients with persistent atrial fibrillation and the other 47 patients with paroxysmal atrial fibrillation;additionally,40 healthy physical examiners were selected as the control group. Enzyme-linked immunosorbent assay（ELISA） was adopted to detect plasmic CNP level,and ultrasonic cardiogram was ap-plied to measure cardiac structure. Results The plasmic CNP levels in AF groups [paroxysmal atrial fibrillation group was （26.46＆#177;9.32）pg/mL,persistent atrial fibrillation group was（30.98＆#177;12.20）pg/mL and permanent atrial fibrillation group was（70.62＆#177; 20.30）pg/mL] were significantly higher than those of the control group[（15.25＆#177;5.48） pg/mL] with statistically significant difference （P＆lt;0.05）. The plasmic CNP level in the permanent atrial fibrillation group was significantly higher than that in the persistent and paroxysmal atrial fibrillation groups,and the difference was statistically significant（P＆lt;0.05）. Conclusion The plasmic CNP level of the patients with the atrial fibrillation increases ,and the plasmic CNP level in the patients with permanent atrial fibrillation is higher than that in the patients with persistent and paroxysmal atrial fibrillation.