当归补血汤治疗绝经过渡期的临床研究

Effect of Dang Gui Buxue Tang on menopausal syndrome among Chinese women in Hong Kong

目的通过口服不同剂量的当归补血汤（DBT），探寻对更年期症状最有效的剂量。方法采用随机双盲剂量递增临床研究，观察DBT对控制更年期血管舒缩症状的最佳剂量。DBT制剂按当归黄芪1：5的比例制成。采用更年期生存质量量表（MENQOL）、更年期症状量表对更年期症状进行评估。受试者随机分为3组，分别给予1．5、3、6g／d剂量的DBT。给药前测定基线值，给药后每月进行1次评估，研究为期3月。结果更年期症状量表结果显示，高剂量组潮热症状与给药前相比显著减少（P〈0．01）。中高剂量组夜汗症状与给药前相比，有明显减少（P〈0．01）。MENQOL评价显示，3个剂量组的血管舒缩症状均显著减少，高剂量组最为显著。结论本研究结果显示，每日6g的DBT疗效最为明显，可减少更年期血管舒缩症状30％～50％。

Objective This present study aimed to investigate the effects of different doses of the Chinese herbal preparation （DangGui Buxue Tang, DBT） on the vasomotor symptoms. Methods This was a randomized, double-blind, dose escalation study on the effect of DBT on the vasomotor symptoms.The preparation was made in a ratio of 1：5 Dang Gui （ Radix Angelicae） to Huangqi （ Radix Astragali）. Doses of 1.5 g, 3 g and 6 g were administered daily. Symptoms were as- sessed using the Greene Climacteric Scale and the vasomotor domain of the Menopause-Specific Quality of Life （MENQOL）. Subjects were randomly assigned to receive one of the three trial doses and were assessed at baseline and then at monthly intervals for 3 months. Results Using the Greene Climacteric Scale, hot flushes significantly decreased in the high dose group compared with baseline （P〈0. O1 ）. Night sweats significantly decreased in both the middle and high dose groups compared with baseline （P〈O. 01 ）. In the vasomotor domain of the MENQOL, hot flushes were significantly reduced in all groups, with the greatest effect in the high dose group. For night sweats, there was a significant reduction in all dose groups, with the greatest effect also in the high dose group （47%）. Conclusions This study shows that a dose of 6 g DBT daily is most effective in reducing vasomotor symptoms, which decreased by 30%-50% among the users.