神经电生理检查对吉兰-巴雷综合征的早期诊断价值研究

DIAGNOSIS VALUE OF ELECTRO-PHYSIOLOGICAL TESTS IN GUILLAN BARRE SYNDROME

目的:探讨神经电生理检查对吉兰-巴雷综合征早期诊断的价值。方法:对入组的67例病人的神经电生理检查进行回顾性分析,其中病程5 d^4 w,最终诊断为吉兰-巴雷综合征的37例病人录入研究组(Ⅰ组),另外30例正常人录入对照组(Ⅱ组)进行分析,两组分别进行上下肢神经传导速度、波幅及F波检测。上肢主要检查正中神经、尺神经的感觉运动传导速度、波幅及尺神经F波检测;下肢主要检查腓总神经、胫神经运动神经传导速度、波幅及腓肠神经传导速度、波幅及胫神经F波检测,对全部结果进行分析。结果:在受检神经中,Ⅰ组感觉神经、运动神经的传导速度、波幅及F波潜伏期、出现率异常较Ⅱ组有显著差异(P<0.001)。结论:神经传导速度、波幅及F波潜伏期、出现率检测可以作为吉兰-巴雷综合征早期诊断的一个重要手段,在结合临床症状及体征的基础上,可以有效的提高对吉兰-巴雷综合征早期诊断率,从而到达早期治疗,缩短病程,改善病人临床转归的目的。

Objective：Discussing the early diagnosis value of electro-physiological tests in Guillan Barre Syndrome（ GBS） . Methods：This study was carried out to analyze and compare 67 patients whose courses of disease were 5 days to 4 weeks. 37 clinically diagnosed GBS patients were put into the studying group（ Group I） and the other 30 healthy human beings were put into the control group（ Group II） . The nerve conduction velocities, amplitudes and F-waves of their upper and lower limbs were tested in both of the groups. Upper limbs：motor and sensation nerve conduction velocities,amplitudes of both median,ulnar nerves and F-wave of ulnar nerve were checked;lower limbs：conduction velocities and amplitudes of peroneal, tibial motor, sural nerves and F-wave of tibial nerve were tested and analyzed. Results：of all the tested persons,abnormalities of conduction velocities,amplitudes and F-wave latencies of sensory and motor nerves in Group I can be obviously seen compared with Group II（ P〈0. 001）. Conclusion：conduction velocities of nerves, amplitudes, F-wave latencies and rate of emergence tests play an important role in early diagnosis of GBS. Combined with clinical symptoms and signs, they can help to improve the early diagnosis, early treatment of GBS patients, cut down their courses of disease.