4种尿微量蛋白在糖尿病肾病早期诊断的价值

Value of Four Kinds of Microalbuminuria in Early Diagnosis of Diabetic Nephropathy

目的探讨尿微量白蛋白(urinary microalbumin,MAlb)、β2微球蛋白(β2-MG)、免疫球蛋白G(IgG)、转铁蛋白(TRF)对糖尿病肾病(DN)的早期诊断价值。方法选取115例2型糖尿病患者及50例健康体检者,根据糖化血红蛋白(HbA1C)水平将患者分组,采用免疫比浊法对受检者尿液各项指标进行测定、比较。结果 2型糖尿病患者各指标与健康体检人群存在显著差异(P<0.01),血糖控制良好组各项指标水平明显低于血糖控制不良组。尿MAlb与β2-MG联合检测阳性率可达83.5%。结论 MAlb的检测对糖尿病肾病早期诊断具有重要意义,联合测定有助于提高早期诊断的敏感性,有利于早期发现和治疗。

Objective To discuss diagnostic value of microalbuminuria （mAlb）, beta 2 microglobulin （ 13 2 - MG）, immunoglobulin G （IgG）, transferrin （TRF） on early diabetic nephropathy （DN）. Methods 115 cases of type 2 diabetes and 50 healthy subjects were in- cluded, and patients were grouped according to glycated hemoglobin （HbA1C） levels. Glycated hemoglobin （HbA1 C） was measured by immunoturbidimetric assay. Results There was significant difference in each index （ P 〈 0. 01 ） between type 2 diabetes patients and healthy people. Good blood sugar control group were significantly lower than that in poor glycemic control group. The combined detection of mAlb and 13 2 - MG positive rate reached 83.5%. Conclusion Detection of microalbuminuria is of great value for the early diagnosis of diabetic nepbropath~＇.