老年人溃疡性结肠炎患者临床分析

Clinical characteristics of elderly patients with ulcerative colitis

目的探讨60岁及以上老年溃疡性结肠炎（UC）患者的临床特点。方法选取溃疡性结肠炎的住院患者166例，对老年UC（年龄≥60岁）患者35例与非老年（20～59岁）UC患者131例的临床特点进行分析，比较二者间的差异。结果两组中，男性患者数均多于女性。非老年组和老年组腹泻为79例（60．3％）与16例（45．7％），差异无统计学意义（χ2=2．40，P〉0．05）；腹痛为67例（51．1％）与11例（31．4％），差异有统计学意义（χ2=4．31，P〈0．05）；便血115例（87．8％）与30例（85．7％），差异无统计学意义χ2=0．00，P〉0．05）。两组均以轻、中度患者为主。非老年组和老年组重度患者分别为36例（27．5％）、4例（11．4％），组间比较差异有统计学意义（χ2=3．89，P〈0．05）；全结肠型在老年组发生率为31．4％（11例），低于非老年组51．1％（61例），差异有统计学意义（χ2=4．31，P〈0．05）。结论老年溃疡性结肠炎患者中，腹痛发生率低，重度患者比例较高，全结肠型发生率低，直肠型发生率高。

Objective To analyze the clinical characteristics of ulcerative colitis （UC） in elderly patients. Methods A total of 166 cases with diagnosed UC were recruited. The clinical characteristics were compared between the elderly group （n=35, ≥60 years） and the young group （n =131, 20-59 years）. Results The number of male patients were more than female patients in both groups. The incidence of abdominal pain was significantly lower in the elderly group than in young group （P〈0.05）. The number of severe patients were significantly lower in the older group than in young group. Severe UC prevalence was 27.5% （36 cases） in the young versus 11.4% （4 cases） in the elderly （χ2 =3.89, P〈0.05）. The prevalence of total colitis was lower in elderly group than in young group （31.4% （11 cases） vs 51.1% （61 cases）, χ2 = 4.31, P〈0.05], however, the prevalence of proctitis is more common in the elderly than in young group. The extra-intestinal manifestations and the ratio of receiving immune inhibitor and operation showed no significant differences between the two groups. Conclusions Compared with young group, there are a lower incidence of abdominal pain, a higher number of severe patients, a lower incidence of total colitis, and a higher incidence of proctiits in elderly group.