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变应性鼻炎是临床严峻挑战 被引量:18

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摘要 变应性鼻炎(AR)是变应原(过敏原)作用于特应性个体而激发的IgE介导的鼻黏膜炎性疾病,主要症状包括鼻痒、喷嚏、流涕、眼痒和鼻塞等,病程慢性迁延,间或出现急性发作特征.从疾病的发病机制来看,AR是全身免疫系统异常在鼻黏膜局部的表现,变应原是直接的致病因素,患者的遗传特征是易感因素,环境卫生程度、空气污染程度等是重要的影响因素.从疾病的临床特征来看,50%的AR患者同时患有慢性鼻-鼻窦炎(CRS),表明二者关联密切[1],2001年变应性鼻炎及其对哮喘的影响(allergic rhinitis and its impact on asthma,ARIA)指南的发表确立了AR与哮喘的密切关联[2].
作者 张罗
出处 《中华耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2014年第4期265-267,共3页 Chinese Journal of Otorhinolaryngology Head and Neck Surgery
基金 国家自然科学基金杰出青年基金(81025007) 北京市自然科学基金(7131006) 首都卫生发展科研专项重点攻关项目(2011-1017-06) 北京市重点实验室2012年阶梯计划项目(Z121107009212032) 卫生部2012年度公益性行业科研专项(201202005)
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参考文献29

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二级参考文献45

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