制备工艺参数对氟离子和碳酸根复合掺杂纳米羟基磷灰石的影响

Effect of Preparation Parameters on Nanosized Hydroxyapatite Co-doped by Fluoride and Carbonate Ions

通过共沉淀法制备了氟和碳酸根复合掺杂纳米羟基磷灰石(CFHA)。研究了合成温度、掺杂离子浓度和pH值对CFHA形貌、替代类型和替代量的影响。用透射电镜观察合成粉体的形貌,用红外光谱和碳硫仪表征了碳酸根替代的类型和含量,用氟选择电极法测定了样品中的氟含量。结果表明:合成温度、碳酸根掺杂浓度和pH值对CFHA形貌有明显影响。随着合成温度的升高、碳酸根掺杂浓度和pH值的减小,晶粒尺寸和长径比增加;合成粉体中氟和碳酸根含量随掺杂离子浓度的增加而非线性增加,但实际替代量与理论计算值有较大偏差;高pH值有利于碳酸根和氟的替代。

Nano-size hydroxyapatite co-doped with fluoride and carbonate ions （abbreviated as CFHA） was prepared by coprecipitation method. The effects of synthesis temperature, doping concentration and the pH value on the morphology, substitution type and content of CFHAs were investigated. The morphologies of synthesized powders were observed by Transmission Electron Microscope （TEM）. The substitution types and contents of carbonate were analyzed by Fourier Transform Infrared Spectroscope （FTIR） and Carbon-sulfur Element Analyzer respectively. The fluoride contents in CFHA were determined by F-ion selective electrode. The results show that the size and aspect ratio of CFHA crystals increase as the synthesis temperature increasing, as well as the decrease of carbonate concentration and pH value. The fluoride and carbonate contents in CFHA crystals increase nonlinearly with initial doping concentration, and the actual substitution content has a large deviation from the theoretical value. The high pH value is in favor of carbonate and fluoride substitution.