转录因子GLI1在肿瘤发生与侵袭转移作用中的机制

Mechanism of transcription factor GLI1 in the tumorigenesis, invasion, and metastasis of tumors

哺乳动物Hedgehog基因家族包括3个成员:Sonic hedgehog(SHH)、Desert hedgehog(DHH)和Indian hedgehog(IHH)。SHH信号通路主要由分泌型信号糖蛋白SHH配体、跨膜蛋白受体PTCH和另一跨膜蛋白SMO的复合物,以及3种GLI蛋白的下游转录因子GLI1、GLI2、GLI3组成。作为最经典的信号通路之一,SHH信号通路在胚胎发生、发育和组织更新等过程中发挥至关重要作用。GLI1是该通路中最重要转录因子之一,其异常活化与纤维化修复、肿瘤的发生发展与侵袭转移、肿瘤耐药和预后等密切相关。本文就GLI1与肿瘤发生与侵袭转移作用机制进行综述。

The mammalian animal gene family Hedgehog includes three members, namely, Sonic hedgehog （SHH）, Desert hedgehog, and Indian hedgehog. As one of the classical signaling pathways, the SHH signaling pathway has a crucial function in the processes of embryogenesis, development, and tissue regeneration. GLI 1 is one of the most important transcription factors in this pathway. Abnormal GLI 1 activation is closely related to fibrosis repair, tumorigenesis, invasion and metastasis of tumors, and tumor drug resistance and prognosis. This article briefly describes the relationship among GLI1, tumorigenesis, and tumor development.