胆管恶性梗阻经内镜支架置入术后胆管炎的危险因素

Risk factors for cholangitis after endoscopic stent placement for malignant biliary obstruction

目的:探讨胆管恶性梗阻患者经内镜支架置入术后发生胆管炎的危险因素.方法:以年龄和性别为匹配条件,对2008-01/2013-12南京医科大学附属苏州医院成功行内镜支架置入术的胆管恶性梗阻患者术后发生胆管炎的40例(C组)及未发生胆管炎的40例(NC组)进行1∶1配对病例对照研究.采用单因素和多因素分析探讨术后胆管炎的可能危险因素.结果:单因素分析结果显示,梗阻部位、支架类型及糖尿病病史在两组间差异有统计学意义;多因素分析结果显示,梗阻部位与术后胆管炎发生显著相关,OR值为8.815,95%CI:1.575-50.009.结论:高位梗阻是经内镜支架置入术后胆管炎的独立危险因素,值得进一步研究.

AIM： To explore the risk factors for cholangitis after endoscopic stent placement for malignant biliary obstruction. METHODS： Eighty malignant biliary obstruc- tive patients who underwent endoscopic stent placement at Nanjing Medical University Af- filiated Suzhou Hospital between January 2008 and December 2013 were divided into two groups： a cholangitis group （n -- 40, with post- endoscopic stent placement cholangitis） and a non-cholangitis group （n = 40, without post- endoscopic stent placement cholangitis）. The two groups were matched for age and gender. The relationship between post-endoscopic stentplacement cholangitis and various factors was investigated by univariate and multivariate analyses. RESULTS： Univariate analysis showed that the location of obstruction, stent type and history of diabetes were significantly different between the two groups. Multivariate analysis demonstrated that the location of obstruction was significantly related to post-endoscopic stent placement chol- angitis （OR = 8.815, 95%CI： 1.575-50.009）. CONCLUSION： Upper biliary obstruction might be an independent risk factor for post-endoscop- ic stent placement cholangitis.