期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

老年犬认知障碍综合征的治疗 被引量：1

下载PDF
导出
摘要 犬的认知障碍综合征（cognitive dysfunction symptom,CDS）是指犬随着年龄增大,在一段时间（18～-24月龄或更长）内,发生记忆、学习、感觉、意识等认知能力下降[1-2],主要表现为迷失方向,与主人互动减少和睡眠规律改变等,这会对犬及其主人的生活造成不利影响.本文简略介绍了犬的CDS研究进展,并重点论述治疗的有关内容.
作者 陈姗姗 陈江楠 孙艳争 夏兆飞
机构地区 中国农业大学动物医学院
出处 《中国兽医杂志》 CAS 北大核心 2014年第2期70-73,共4页 Chinese Journal of Veterinary Medicine
关键词 认知障碍 综合征 治疗 犬 老年 认知能力 CDS 主人
分类号 S858.292 [农业科学—临床兽医学]
  • 相关文献

参考文献21

  • 1Hoskins J D. Geriatrics & Gerontology of the Dog and Cat[M]. 2nd Edition USA:Saunders, 2004.
  • 2Landsberg B, Aranjo J A. Behavior Problems in Geriatric Pets[J]. Veterinary Clinics small animal pratice, 2005(35):675-698.
  • 3Nielson J C, Hart B L, Cliff K D, et al. Prevalence of behavioral changes associated with age-related cognitive impairment in dogs [J]. J Am Vet Med Assoc, 2001,218(11): 1787-1791.
  • 4Hand M S, Thatcher C K, Remillard R L, et al. Small Animal Clinical Nutriton[M]. 5th Edition. The Markmorris Institute, 2010.
  • 5Salvin H E, Mcgreevy P D, Sachdev P S, et al. Under diagnosis of canine cognitive dysfunction: A cross-sectional survey of older companion dogs[J]. The Veterinary Journal, 2010(184):277-281.
  • 6Manteca X. Nutrition and Behavior in Senior Dogs[J]. Topics in Companion Animal Medicine, 2011(26):33-36.
  • 7Osella M C, Re G, Badino P, etal. Phosphatidylserine (PS) as a potential nutraceutical for canine brain aging: A review[J]. Jour- nal of Veterinary Behavior, 2008(3):41-51.
  • 8张弦,许华曦,张云武.β-淀粉样蛋白前体蛋白胞内结构域(AICD)研究进展[J].生命科学,2008,20(2):159-164. 被引量：3
  • 9Bosch M N, Pugliese M, Gimeno-Bay6n J, et al. Dogs with Cog- nitive Dysfunction Syndrome: A Natural Model of Alzheimer' s Disease[J]. Current Alzheimer Research, 2012(9):298-314.
  • 10Azkona G, Garcia-Belengue S, Chacon G, etal. Prevalence and risk factors of behavioural changes associated with age-related cognitive impairment in geriatric dogs[J]. Journal of Small Ani- mal Practice, 2009(50):87-91.

二级参考文献75

  • 1Sastre M, Steiner H, Fuchs IL et al. Presenilin-dependent γ- secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep, 2001, 2(9): 835-41
  • 2Weidemann A, Eggert S, Reinhard FB, et al. A novel epsiloncleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry, 2002, 41(8): 2825-35
  • 3Zhao GJ, Cui MZ, Mao GZ, et al. γ-Cleavage is dependent on ζ-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. J Biol Chem, 2005, 280(45): 37689-97
  • 4Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, et al. Longer forms of amyloid β protein: implications for the mechanism of intramembrane cleavage by γ-secretase. J Neurosci, 2005, 25(2): 436-45
  • 5Kakuda N, Funamoto S, Yagishita S, et al. Equimolar production of amyloid β-protein and APP intracellular domain from β-carboxyl terminal fragment by γ-secretase. J Biol Chem, 2006, 281(21): 14776-86
  • 6Gu YJ, Misonou H, Sato T, et al. Distinct intramembrane cleavage of the β-amyloid precursor protein family resembling T-secretase-like cleavage of Notch. J Biol Chem, 2001, 276(38): 35235-8
  • 7Yu CJ, Kim SH, Ikeuchi T, et al. Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment. Evidence for distinct mechanisms involved in T-secretase processing of the APP and Notchl transmembrane domains. J Biol them, 2001, 276(47): 43756-60
  • 8Zheng H, Koo EH. The amyloid precursor protein: beyond amyloid. Mol Neurodegener, 2006, 1:5
  • 9Scheinfeld MH, Ghersi E, Laky K, et al. Processing of β- amyloid precursor-like protein- 1 and -2 by γ-secretase regulates transcription. J Biol Chem, 2002, 277(46): 44195-201
  • 10Cupers P, Orlans I, Craessaerts K, et al. The amyloid precursor protein (APP)-cytoplasmic fragment generated by γ- secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. J Neurochem, 2001, 78(5): 1168-78

共引文献2

同被引文献3

引证文献1

中国兽医杂志
2014年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部