6,7-二氢-5H-环戊烷并[b]吡啶的合成

Synthesis of 6,7-dihydro-5H- cyclopentano[b] pyridine

以“一勺烩”方法制备中间体O 烯丙基 环戊酮肟 ,无需分离纯化化合物O 烯丙基羟胺 ,热解反应以氧气代替空气 ,制得 6 ,7 二氢 5H 环戊烷并 [b]吡啶 ,反应总收率为 35 %。

O Allyl cyclopentanone oxime intermediate was prepared by the “one pot” method,and the thermolysis of it in oxygen gave 6,7 dihydro 5 H cyclopentano[b]pyridine, the total yield was 35%.