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视黄醇结合蛋白4在2型糖尿病合并代谢综合征中的作用 被引量:2

Effect of retinol binding protein-4 on type 2 diabetes mellitus patients complicated with metabolic syndrome
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摘要 目的探讨视黄醇结合蛋白4及血管内皮功能在2型糖尿病(T2DM)合并代谢综合(MS)征发生、发展中的作用机制。方法将2型糖尿病患者117例根据有无合并代谢综合征分为2型糖尿病合并代谢综合征组(67例)和2型糖尿病不合并代谢综合征组(50例),另设对照组37例。比较各组的一般情况、血脂、糖代谢等生化指标和黄醇结合蛋白4、可溶性血管细胞粘附分子-1的差异。结果 (1)2型糖尿病合并代谢综合征组的血清黄醇结合蛋白4水平明显高于2型糖尿病不合并代谢综合征组组(P<0.01),且两组黄醇结合蛋白4水平均高于对照组(P<0.01);(2)2型糖尿病合并代谢综合征组的血清可溶性血管细胞粘附分子-1水平明显高于2型糖尿病不合并代谢综合征组(P<0.01),且两组可溶性血管细胞粘附分子-1水平均高于对照组(P均<0.01);(3)相关分析显示,血清黄醇结合蛋白4与可溶性血管细胞粘附分子-1、体重指数、腰围、空腹血糖、收缩压、甘油三酯、总胆固醇、低密度脂蛋白胆固醇显著正相关(P<0.01或P<0.05),与高密度脂蛋白胆固醇显著负相关(P<0.05)。结论黄醇结合蛋白4与血管内皮功能障碍可能参与了2型糖尿病合并代谢综合征的发生与发展。 Objective To investigate the role of serum retinol binding protein- 4(RBP4) and the function of endotheliocytes in the pathogenesis of type 2 diabetes mellitus(T2DM) patients complicating with metabolic syndrome(MS). Methods The 117 type 2 diabetes mellitus patients were divided into two groups: T2DM with MS(n=67) and T2DM without MS(n=50), control group included 37 healthy subjects. General condition, lipid profiles, glycometabolism parameters, other serum biochemical parameters RBP4 and serum vascular cell adhesion molecule-1(SVCAM-1) were detected and compared. Results(1)The RBP4 levels in T2DM patients with MS were significantly higher compared with patients without MS(P〈0.01), and the RBP4 levels in patients with T2DM were higher than those in the control group(P〈0.01) respectively;.(2)The SVCAM-1 levels in T2DM patients with MS were significantly higher compared with patients without MS(P0.01), and the SVCAM-1 levels in patients with T2DM were higher than those in the control group(P〈0.01) respectively.;(3) positive correlations between the serum RBP4 level and SVCAM-1, BMI,WC,FPG,SBP, TG,TC and LDL-C were observed(P〈0.01 or P〈0.05). There was a negative correlations between the serum RBP4 level and HDL-C(P〈0.05). Conclusion The serum RBP4 and endothelial dysfunction may play an important role in T2DM complicating MS.
出处 《中国热带医学》 CAS 2014年第2期194-196,共3页 China Tropical Medicine
基金 河北省科技厅资助(No.12276104D-59)
关键词 黄醇结合蛋白4 可溶性血管细胞粘附分子-1 2型糖尿病 代谢综合征 Retinol binding protein-4 Serum vascular cell adhesion molecule-1 Type 2 diabetes mellitus Metabolic syndrome
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参考文献13

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二级参考文献5

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共引文献11

同被引文献18

  • 1王湘芸.视黄醇结合蛋白4与代谢综合征的相关性研究[D].第二军医大学2010
  • 2张玺.视黄醇结合蛋白4与2型糖尿病合并脑梗死的关系研究[D].石河子大学2014
  • 3刘士兵.血清视黄醇结合蛋白4与2型糖尿病下肢动脉病变的关系研究[D].河北医科大学2012
  • 4张慧.血清视黄醇结合蛋白-4与2型糖尿病及肥胖的相关性研究[D].苏州大学2008
  • 5Thawnashom K, Tungtrongchitr R, Chanchay S, et al. Association between retinol-binding protein and renal function among Asian subjects with type 2 diabetes mellitus: a cross-sectional study[J]. Southeast Asian J Trop Med Public Heahh, 2011,42(4):936-945.
  • 6Yschoner A, Sturm W, Engl J, et al. Retinol-binding protein 4, visceral fat, and the metabolic syndrome: effects of weight loss[J]. Obesity (Silver Spring), 2008,16(11):2439-2444.
  • 7Ingelsson E, Sundstrsm J, Melhus H, et al. Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly[j]. Atherosclerosis, 2009, 206(1):239 -44.
  • 8Pontiroli AE, Alberto M, Paganelli M, et al. Metabolic syndrome, hypertension, and diabetes mellitus after gastric banding: the role of aging and of duration of obesity[J]. Surg Obe Relat Dis,2013: 9(6) :894- 900.
  • 9Numao S, Sasai H, Nomata Y, et al. Effects of Exercise Training on Circulating Retinol-Binding Protein 4 and Cardiovascular Disease Risk Factors in Obese Men[J]. Obes Facts, 2012,5(6):845-855.
  • 10Alkharfy KM, A1-Daghri NM, Vanhoutte PM, et al. Serum retinol- binding protein 4 as a marker for cardiovascular disease in women[J]. PLoS One, 2012;7(10):e48612.

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