摘要
目的:分析结直肠癌中伊立替康化疗疗效及毒性预测分子标志物。方法:收集国内外发表的文献并对伊立替康作用机制、化疗的疗效和不良反应等进行分析。结果与结论:结直肠癌是最常见的恶性肿瘤之一,化疗在其综合治疗中发挥着重要的作用。由于肿瘤的异质性以及患者个体的差异性,不同的患者对于化疗的疗效和不良反应差异很大,因此寻找化疗药物的潜在分子标志物是很重要的,可以为患者制定个体化的治疗方案。
Objective： To analyze efifcacy and predictive molecule markers associated toxicity of irinotecan for colorectal cancer. Methods： We collected related articles and analyze mechanism, efifciency , toxicity of chemotherapy associated irinotecan. Results and Conclusion： Colorectal cancer is one of the most common malignant disease worldwide. And chemotherapy plays an important role in its comprehensive treatments. Because of the tumor heterogeneities and individual differences of patinets, the efficiency and toxicity of chemotherapy varied across individuals. Therefore, identifying potential predictive molecules of certain cytotoxic agents is of much helpful to fertilize individualized treatment for patients.
出处
《临床药物治疗杂志》
2014年第2期9-13,共5页
Clinical Medication Journal
关键词
结直肠癌
伊立替康
分子标志物
Colorectal Cancer
Irinotecan
Molecular markers
