幽门螺杆菌阴性十二指肠球部溃疡的诊断研究

Diagnosis research of Helicobacter pylori negative duodenal ulcer

目的 探讨幽门螺杆菌（Hp）阴性的十二指肠球部溃疡的诊断方法,为Hp阴性十二指肠球部溃疡的诊断提供参考依据.方法 回顾性分析2010年1月至2013年1月收治的140例十二指肠球部溃疡患者的临床资料,采取不同的检测方法进行Hp阴性检查确诊.结果 140例患者中,Hp阳性90例（64.3％,90/140）,Hp阴性50例（35.7％,50/140）.病理学染色检查Hp阴性30例（21.4％,30/140）,13C呼气试验检查Hp阴性35例（25.0％,35/140）,基于侵入性的检查方法（病理学染色检查）及13C呼气试验两种检查均为Hp阴性的有40例（28.6％,40/140）.结论 Hp阴性十二指肠球部溃疡诊断复杂,需要综合各种检查手段和考虑其他因素,并排除各种假阴性.

Objective To investigate the diagnosis methods of Helicobacter pylori （Hp） negative duodenal ulcer,to provide clinical analysis for diagnosing Hp negative duodenal ulcer.Methods Reviewed 140 patients with duodenal ulcer who treated from January 2010 to January 2013.Adopted different detection methods of Hp negative diagnosis.Results In 140 patients,Hp positive was 90 cases（64.3%,90/140） and Hp negative was 50 cases （35.7%,50/140）.Pathology examination negative was 30 cases （2 1.4%,30/1 40）,13C breath test negative was 35 cases （25.0%,35/140）,the invasive methods based on pathology examination and 13C breath test negative was 40 cases （28.6%,40/140）.Conclusion The diagnosis of Hp negative duodenal ulcer is more complex,need comprehensive factors,to exclude various possibility of false negative.