期刊文献+

甲氨蝶呤治疗银屑病临床观察 被引量:5

下载PDF
导出
摘要 目的:探讨甲氨蝶呤在银屑病治疗中的临床疗效及药物安全性。方法对本科诊治40名银屑病患者随机分为观察组和对照组各20例,两组均规律口服用药治疗12周,观察组给予甲氨蝶呤5-15 mg/周,对照组阿维A0.5-0.65 mg/(kg·d),对比治疗后进行总结性分析。结果患者应用甲氨蝶呤治疗后,有效率90%;阿维A治疗后,有效率65%;观察组主要不良反应为胃肠道反应,对照组主要为头痛、口干、口唇炎、瘙痒等,患者停药后均恢复正常。结论甲氨蝶呤在银屑病的治疗中,效果好,不良反应低,值得推广。
作者 龙亭
出处 《中国实用医药》 2014年第4期161-162,共2页 China Practical Medicine
  • 相关文献

参考文献3

二级参考文献31

  • 1何玉清,张锡宝,李常兴,刘玉梅,黄振明,陈绍谦.阿维A与甲氨喋呤治疗银屑病的疗效对比分析[J].中国皮肤性病学杂志,2005,19(6):346-348. 被引量:9
  • 2杜明,李显平,王久江.阿维A与甲氨蝶呤治疗寻常性银屑病疗效观察[J].国际皮肤性病学杂志,2006,32(6):404-404. 被引量:3
  • 3[1]Weinstein GD, Frost P. Methotrexate for psoriasis, A new therapeutic schedule. Arch Dermatol, 1971, 103 ( 1 ): 33 -38.
  • 4[2]Said S, Jeffes EW, Weinstein GD. Methotrexate. Clin Dermatol, 1997, 15(5) :781 - 797.
  • 5[3]Primka EJ 3rd, Camisa C. Methotrexate - induced toxic epidermal necrolysis in a patient with psoriasis. J Am Acad Dermatol, 1997, 36(5 Pt 2): 815 - 818.
  • 6[5]Sprecher E, Bergman R, Sprecher H, et al. Reduced folate carrier (RFC - 1) gene expression in normal and psoriatic skin. Arch Dermatol Res, 1998, 290(12) :656- 660.
  • 7[6]Jeffes EW 3rd, McCullough JL, Pittelkow MR, et al. Methotrexate therapy of psoriasis: differential sensitivity of proliferating lymphoid and epithelial cells to the cytotoxic and growth - inhibitory effects of methotrexate. J Invest Dermatol, 1995, 104(2): 183-188.
  • 8[7]Jeffes EW 3rd, Lee GC, Said S, et al. Elevated numbers of proliferating mononuclear cells in the peripheral blood of pso riatic patients correlate with disease severity. J Invest Dermatol, 1995, 105(6): 733- 738.
  • 9[8]Yamasaki E, Soma Y, Kawa Y, et al. Methotrexate inhibits proliferation and regulation of the expression of intercellular adhesion molecule - 1 and vascular cell adhesion molecule - 1 by cultured human umbilical vein endothelial cells. Br J Der matol, 2003, 149( 1 ): 30 - 38.
  • 10[9]Piskin G, Heydendael VM, de Rie MA, et al. Cyclosporin A and methotrexate are equally effective in reducing T cell numbers in psoriatic skin lesions but have no consistent effect on IFN - gamma and IL - 4 expression in psoriatic skin in situ. Arch Dermatol Res, 2003, 294(12) :559 - 562.

共引文献43

同被引文献36

引证文献5

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部