大蒜素注射液治疗急性加重期肺心病

Observatipn on curative effects of galic injection on treating acutely deteriorative phase of cor pulmonal

目的观察大蒜素注射液治疗肺源性心脏病(肺心病)急性加重期的临床疗效。方法将60例患者随机分为2组,各30例。2组均予吸氧、抗感染、强心、利尿、解痉平喘、纠正电解质和酸碱失衡等对症治疗。治疗组加用大蒜素注射液60ml(加入5％葡萄糖500ml内)静滴,每日一次,10次为一个疗程。结果治疗组总有效率为93.3％,显著高于对照组总有效率73.3％,(x^2=4.32,P<0.05)。治疗组治疗后全血粘度、全血还原粘度及红细胞聚集指数均较对照组治疗后显著降低(P均<0.05);动脉血氧分压(PaO_2)显著升高,二氧化碳分压(PaCO_2)显著降低,与对照组治疗后比较也有显著性差异(P均<0.05)。结论肺心病急性加重期患者在西医综合治疗基础上加用大蒜素注射液可提高临床疗效,改变血液流变性和血气指标。

Objective To observe the clically curative effects of galic injection treating acutely deteriorative phase of cor pulmonale. Methods 60 patients were randomly divided into two groups: (30 cases for each group) . The symptomatic therapies, including oxygen, controlling infection, intropic, diuretic, releiving buonchial spasm and wheeze, correcting electrolyte and acidbase inbalance and so on, wereused to both two groups. Additionally, in treated group galic injection 60ml + 5% glucose 250nl infused intravenously once a day were added for 10 days as a therapeutic course. Results The total effective rate (93.3%) in treated group was significantly higher than that (73.3%) in control group (x = 4.32, P <0.05) . Otherwise, the whole blood viscosity, the whole blood reduced viscosity, and aggregative index of red blood cells after therapy in treated group were signifiocantly lower than those in control group (all P< 0.05), meanwhile in treated group after therapy the PaO was obviously elevated, PaCO depressed, and in comparison with control group the differences were significant (all P<0.05) . Conclusions galic injection combind with general therapy of western medicine for patients with acutely deteriorative phase of cor pulmonale is able to heighten the clinically curative effects and to improve the parameters of blood rheology and blood gas.