变应性鼻炎患者主客观指标相关性研究

Correlation study between subjective and objective indicators in allergic rhinitis patients

目的：分析成人变应性鼻炎患者的血清变应原特异性IgE（Serum allergen specific IgE,sIgE）、皮肤点刺试验（Skin prick test,SPT）及外周血嗜酸性粒细胞（Peripheral eosinophilic,Eos）计数与鼻部症状视觉模拟量表评分（Visual analogue scale,VAS）的相关性.方法：2009年9月～2011年5月我科就诊的变应性鼻炎患者66人,男31人,女35人,年龄20～76岁,平均（34.17±13.51）岁.通过病史、典型试验量表对喷嚏,清涕,鼻堵,鼻痒评分,分别分析血清sIgE、SPT与VAS评分和外周血嗜酸性粒细胞计数之间的相关性.结果：血清sIgE和皮肤点刺试验显著正相关（r=0.532,P＜0.01）;血清sIgE、SPT与鼻部症状VAS总分及外周血嗜酸性粒细胞计数均无明显相关性.结论：血清sIgE和皮肤点刺试验对诊断变应性鼻炎都具有显著意义,皮肤点刺试验反应、血清特异性IgE水平和外周血嗜酸细胞计数不能正确反应变应性鼻炎患者的临床症状和生活质量状况.

Objective：To analyze the correlation among serum allergen specific IgE （sIgE）,the skin prick tests（SPT）,total IgE,peripheral eosinophil（Eos） and nasal symptoms visual analogue scale （VAS）in adult patients with allergic rhinitis.Methods：66 adult patients aged from 20-76 with allergic rhinitis were choosed during 2009.9-2011.5.Among these patients 31 was male,35 female,mean age was （34.17 ± 13.51）.Allergic rhinitis was diagnosed by the history,typical symptoms,SPT,sIgE,and count peripheral eosinophil.VAS was used to assess the symptoms severity including sneezing,rhinorrhoea,nasal plugging and itch.analyze the correlation among sIgE,SPT,TIgE,Eos and VAS.Results：There are significant correlation between sIgE and SPT（r =0.532,P ＜ 0.01） ;There was no correlation between sIgE,SPT and VAS,Eos;The higher SPT positive react,the higher sIgE react.Conclusion：sIgE and SPT are significant in the diagnosis of allergic rhinitis,sIgE,SPT,Eos can＇t reflect the clinical symptoms in allergic rhinitis patients.