应用药代动力学/药效学原理指导肺部感染的抗菌治疗

Antimicrobial Therapy of Pulmonary Infections Guides by Pharmacokinectic/ Pharmacodynamic Principle on Antibiotic

抗菌药物的临床疗效除取决于抗菌谱、抗菌活性外 ,还取决于它的药代动力学和药效学参数。主要叙述了抗菌药物在呼吸系统的穿透力和同疗效相关的药效学参数。并对肺部感染的治疗方案应当根据药代动力学

The Clinical effiency of antimicrobial therapy depend on the pharmacokinectic/pharmacodynamic parameters of antibiotics except antibacterial spectrum and activity. The penetration of antibiotics in the respiratory organ and pharmacokinectic/pharmacodynamic parameters correlating with antibacterial efficiency are descrided. It is emphasized that antibiotic treatment regime on the pulmonary infections should be based the pharmacokinectic/pharmacodynamic principle.