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蛇毒凝血酶原激活组分的研究概况

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摘要 蛇毒是一类复杂的具有多种生物学活性的蛋白质和蛋白多肽.目前已经分离纯化出许多作用于血液凝固酶促级联反应过程中的一个或多个环节的蛇毒组分,包括FⅡ、FⅤ、FⅦ、FⅩ等激活剂以及直接使纤维蛋白原凝聚的蛇毒凝血酶样酶.蛇毒蛋白中有一类凝血毒素作用于血液凝固酶促级联反应,发挥止血作用,作用方式：（1）激活内源性和外源性凝血途径中的各种凝血因子,从而促进血液凝固.（2）激活凝血酶原,从而发挥凝血作用.（3）直接使纤维蛋白原变成纤维蛋白,即类似凝血酶样作用[1].现已在临床上广泛使用的立止血是从巴西矛头蝮蛇的毒液中分离、提纯而得到的一种高纯度蛇毒凝血毒素制剂.目前还没有蛇毒凝血因子激活组分,特别是蛇毒凝血酶原激活酶被开发上市为止血制剂.因此开发蛇毒凝血酶原激活酶有着重要的意义.现就近年来对蛇毒凝血酶原激活组分的研究概况综述如下.
作者 陈春枚 林文宏
机构地区 福建医科大学附属龙岩市第一医院药剂科
出处 《蛇志》 2014年第1期89-91,共3页 Journal of Snake
关键词 蛇毒 凝血酶原激活物 研究概况
分类号 R996.3 [医药卫生—毒理学] R977.3 [医药卫生—药品]
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参考文献19

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2014年 第1期

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