结直肠癌患者血清淀粉样蛋白、D二聚体和CA724水平对肿瘤转移的预测

The changes of serum amyloid A(SAA), plasma D-dimer and tumer marker CA724 for predicting tumor metastasis of patients with colorectal cancer

目的研究结直肠癌患者血液中血清淀粉样蛋白(SAA)、D二聚体和CA724指标的变化对结直肠癌患者肿瘤转移的预测、评估。方法选择结直肠癌患者58例及良性疾病患者55例,于术前采血并检测SAA、血浆D二聚体和CA724的水平,随后进行统计学分析。另外,结直肠癌患者组内按照术后病理分期(AJCC/UICC)分为无区域淋巴结及无远处转移组、有区域淋巴结及无远处转移组、远处转移组,对3组间SAA、D二聚体、CA724进行比较。结果结直肠癌患者的SAA、D二聚体、CA724水平较对照组显著升高(P<0.05)。SAA在结直肠癌患者无区域淋巴结及无远处转移组、有区域淋巴结及无远处转移组、远处转移组之间差异有统计学意义;CA724在无区域淋巴结及无远处转移组、有区域淋巴结及无远处转移组、远处转移组之间差异无统计学意义。在结直肠癌患者的各亚组中,远处转移组的SAA、D二聚体水平明显高于有区域淋巴结及无远处转移组、无区域淋巴结及无远处转移组(P<0.05)。结论检测血液SAA、CA724及D二聚体水平对筛选结直肠癌患者区域淋巴结转移及远处转移可能有一定的指导意义。

Objective To explore the changes of serum amyloid A （SAA）, plasma D-dimer and tumer marker CA724 for predicting tumor metastasis of patients with colorectal cancer. Methods Preoperative SAA, D-dimer and CA724 were measured in 58 patients with colorectal and 55 patients with benign disease, and they were analyzed with statistics method. In addition, according to pathological TNM （AJCC/UICC TNM）, the patients with colorectal were divided into no metastasis group, regional lymph node metastasis group and distant metastasis group for comparing SAA, D-dimer and CA724 between groups. Results SAA, D-dimer and CA724 levels were signiifcantly higher in patients with colorectal carcinoma than those with benign diseases （P＆lt;0.05）. SAA test showed that there was statistical significance between no metastasis group, regional lymph node metastasis group and distant metastasis group, and there was no statistical signiifcance by CA724. SAA and D-dimer levels in distant metastasis group were obviously higher than that of no metastasis group and regional lymph node metastasis group （P＆lt;0.05）. Conclusion There is guiding signiifcance for conifrming regional lymph node metastasis and distant metastasis in patients with colorectal to detect SAA CA724 and D-dimer levels.