吡喃阿霉素联合治疗晚期恶性肿瘤128例

The clinical efficacy of pirarubicin based combination chemotherapy for 128 cases of various advanced malignancies

目的 观察以吡喃阿霉素为主的联合化疗治疗晚期恶性肿瘤的疗效和毒副作用。方法 12 8例晚期恶性肿瘤病人接受以吡喃阿霉素为主的联合化疗。均治疗 2周期以上 ,3～ 4周为一疗程。结果 本组 12 8例中 ,CR 2 6例占2 0 .3 % ,PR 48例占 3 7.5 % ,总有效率 5 7.8%。恶性淋巴瘤、乳腺癌、胃癌、头颈部癌、肺癌的有效率分别为 85 .7% (3 6/4 2 )、5 5 .6% (10 /18)、44.4% (8/18)、43 .8% (7/16)和 40 .0 % (8/2 0 )。结论 以吡喃阿霉素为主的联合化疗方案是治疗晚期恶性肿瘤的有效方法 ,吡喃阿霉素的毒性主要是骨髓抑制 。

Objective To evaluate the effects and toxicites of pirarubicin(THP)combination chemtherapy on various advanced malignancies.Methods 128 patients with various advanced malignancies were treated with pirarubicin combination chemotherapy for more than 2 courses,repeated in 3 or 4 weeks.Results The results showed that the overall response rate was 57.8%(74/128),with 26 cases with complete response and 48 partial response.The response rates of malignant lymphoms,breast cancer,gastric cancer,head and neak acncer,and lung cancer were 85.7%936/42) 55.6%(10/18),44.4%(8/18),43.8%(7/16)and 40.0%(8/20),respectively.Conclusions pirarubicin(THP) combination chemotherapy regimen is an effective treatment for patints with various advanced malignancies.Myelosuppression is the most commonly seen toxicity of pirarubicin.other side responses were mild. [