581例慢性荨麻疹皮肤点刺试验阳性患者临床特征分析

A clinical characteristics analysis of 581 chronic urticaria patients with positive skin prick test

目的探讨皮肤点刺试验阳性数目与慢性荨麻疹临床特征之间的关系。方法分析21种变应原检测的581例慢性荨麻疹皮肤点刺试验阳性患者的资料。结果皮肤划痕试验阳性患者的变应原阳性数目高于皮肤划痕试验阴性者(P=0.00),对多种变应原致敏的皮肤划痕试验阳性患者频率高于皮肤划痕试验阴性患者(P=0.03);伴发其他过敏性疾病(过敏性鼻炎、哮喘、过敏性结膜炎)患者的变应原阳性数目高于单纯的慢性荨麻疹患者(P=0.03),对多种变应原致敏的伴发其他过敏性疾病患者频率高于单纯的慢性荨麻疹患者(P=0.04)。结论皮肤点刺试验阳性数目(≥4种)与慢性荨麻疹患者合并皮肤划痕试验阳性、伴发过敏性疾病(哮喘、过敏性鼻炎、过敏性结膜炎)密切相关,有助于慢性荨麻疹临床特征评估。

Objective To perform an association analysis between the number of positive skin prick test （SPT）responses and chro-nic urticaria clinical characteristics.Methods A total of 581 individuals with chronic urticaria underwent SPT with a panel of 21 biologically standardized aeroallergens,and these data were analyzed retrospectively.Results Skin scratch test positive patients with chronic urticaria held a higher average number of positive SPT responses than that of the patients with skin scratch test negative （P=0.002）;the frequency of skin scratch test positive patients with chronic urticaria with poly-sensitization was significantly higher than that of the patients with skin scratch test negative （P=0.03）.Similarly,patients with concomitant allergic diseases （asthma,allergic rhinitis,allergic conjunctivitis）held a higher average number of positive SPT responses than that in those without concomitant allergic diseases （P=0.03）,and the frequency of patients with concomitant allergic diseases with poly-sensitization was also significantly higher than those with only chronic urticaria （P=0.04）.Conclusion The number of positive SPT responses （≥4）may associate with skin scratch test positive and concomitant allergic dis-eases （asthma,allergic rhinitis,allergic conjunctivitis）in chronic urticaria,which helps to assess the clinical features of chronic urticaria.