CT引导射频消融术治疗中晚期非小细胞肺癌的临床疗效分析

The Clinical Efficacy Analysis of CT-guided Radiofrequency Ablation in Treating Middle or Late NSCLC

目的:探讨在CT引导下采用射频消融方法进行治疗局部的晚期非小细胞肺癌的临床效果、安全性及CT值对射频消融治疗术中的指导意义。方法:通过观察晚期非小细胞肺癌射频消融过程中CT值变化(治疗前、治疗后即刻、治疗后1月与3月)及术中、术后并发症来考察本方法的临床效果。结果:18例病人行射频消融术后,CT值明显降低,术后即刻、术后1月与3月与术前CT值均数比较,均具有显著性差异;18例患者肿瘤治疗总有效率为85.0%。并发症包括气胸3例占16.66%,肺内出血5例占27.78%,轻微灼痛2例占11.11%,发热12例占66.67%。结论:射频消融术治疗肺癌是一种简单、安全、微创、有效的方法,其与放化疗有机结合,将极大地提高肿瘤的局部控制率,提高了患者的生存质量,值得在临床推广运用。

Objective： To study the clinical efficacy and security of CT-guided radiofrequency ablation in treating partly middle or late Non- small cell lung cancer, and study the directive significance of CT in radiofrequency ablation therapy. Methods： To investigate the clinical efficacy by observe the change of CT value （prior treatment, post-treatment, after 1 month treatment, after 3 month treatment）, the complications in intraoperative and Postoperative. Results： The CT value of 18 patients decreased obviously, and the CT value of prior treatment compare with the post-treatment, after 1 month treatment, after 3 month treatment have significant deviation. The total effective rate all of the patients is 85.0%.The complieationsinclude pneumothorax 3/18 （16.66%）, pulmonary hemorrhage 5/18 （27.78%）,thermalgia2/18 （11.11% ）,generate heat 12/18 （66.67%）.Conclusion： CT guided RFA is a easy, safe, minimal invasive and effective method, combine with the chemotherapy or radiotherapy can enhance the local control rate and quality of life enormously, is worthy of clinical use.