配偶淋巴细胞注射联合黄体支持疗法在复发性流产患者中的应用观察

Application effect of spouse lymphocyte injection combined with luteal support therapy in patients with recurrent early abortion

目的观察配偶淋巴细胞注射联合黄体支持在早期复发性流产患者中的应用效果。方法将184例URSA患者随机分为3组,A组(96例)同时接受配偶淋巴细胞注射加黄体支持治疗,B组(41例)排卵指导同房后接受黄体支持(地屈孕酮片+黄体酮+HCG)治疗,C组(47例)单独接受患者配偶淋巴细胞注射治疗,观察3组妊娠成功率、继续妊娠率(妊娠超过3个月)、足月分娩率。结果 A组、B组、C组妊娠成功率为93.75%(90/96)、36.59%(15/41)、27.66%(13/47),A组分别与B组、C组比较P均<0.05;继续妊娠率分别为85.42%(82/96)、29.27%(13/41)、23.40%(11/47),A组分别与B组、C组比较P均<0.05;足月分娩率分别为84.37%(81/96)、29.27%(13/41)、19.15%(9/47),A组分别与B组、C组比较P均<0.05。结论配偶淋巴细胞注射联合黄体支持对提高复发性流产患者妊娠成功率及继续妊娠率有显著效果。

Objective To observe the application effect of spouse lymphocyte injection combined with luteal support in patients with recurrent early abortion. Methods Totally 184 URSA patients were randomly divided into three groups： group A （96 cases） received the spouse lymphocyte injection combined with luteal support therapy, group B （41 cases） re- ceived luteal support（ dydrogesterone ＋ progesterone ＋ HCG）after ovulation, and group C （47 cases） received spouse lym- phocyte injection. The pregnancy success rate and ongoing pregnancy rate （ pregnancy more than 3 months）, full-term de- livery rate of the 3 groups were observed. Results The pregnancy success rate in group A was 27.66% （ 13/47）, ongoing pregnancy rate was 23.40% （11/47）, and full-term delivery rate was 19.15% （9/47）; group B were 36.59% （15/ 41）, 29.27% （13/41）, and 29.27% （13/41） ; and group C were 93.75% （90/96）, 85.42% （82/96）, and 84.37% （81/96）. The pregnancy success rate and ongoing pregnancy rate, full-term delivery rate of group A were significant differ- ent as compared with those of group B or C （ all P 〈 0.05）. Conclusion Spouse lymphocyte injection combined with lute- al support can significantly improve the pregnancy success rate and ongoing pregnancy rate of patients with recurrent early abortion.