原发性青光眼患者血浆血管紧张素Ⅰ,Ⅱ、醛固酮及心钠素含量的测定

Plasma angiotensin Ⅰ, Ⅱ、 aldosterone and cardionatrin in primary glaucoma

目的 探讨原发性青光眼患者血浆中血管紧张素 , 、醛固酮及心钠素的含量 .方法 采用放射免疫分析法检测了 2 8例原发性青光眼 (急性闭角型、慢性闭角型、慢性单纯型 )患者血浆血管紧张素 , 、醛固酮及心钠素的含量 ,并与 10例非青光眼者作对照 .结果 青光眼组患者血浆心钠素水平明显高于对照组 ,对照组为 (2 38.0 0± 186 .7)μg·L- 1 ,急闭青 (发作期 )、慢闭青和慢开青分别为 (5 2 7.5 6±2 17.17) μg· L- 1 、 (4 13.6 2± 2 0 9.94) μg· L- 1 和 (4 0 4.0 0±196 .5 3) μg· L- 1 (P<0 .0 5 ) ;急性闭角型青光眼患者血浆血管紧张素 含量明显低于对照组 ,对照组为 (2 .39± 1.0 5 )μg· L- 1 ,急闭青 (发作期 )为 (1.19± 1.0 2 )μg· L- 1 (P<0 .0 5 ) .其他组与对照组相比无明显改变 .结论 提示血浆心钠素水平的改变与青光眼存在密切关系 ;血浆肾素

AIM To investigate the plasma content of the angiotensin Ⅰ, Ⅱ (AT Ⅰ, Ⅱ), aldosterone (ALD), cardionatrin in primary glaucoma. METHODS Plasma content of AT Ⅰ, Ⅱ, ALD, cardionatrin of 28 cases (acute angle closure glaucoma [AACG] 12 cases; chronic angle closure glaucoma [CACG] 10 cases; chronic angle open glaucoma [CAOG] 6 cases) were measured by radioimmunoassay. RESULTS Level of plasma cardionatrin in glaucoma was higher than that in control; The control group was (238.00±186 7) μg·L -1 , AACG, CACG and CAOG were (527.56±217 17)μg·L -1 , (413.62±209.94)μg·L -1 as well as (404.00±196.53) μg·L -1 respectively ( P <0.05);The level of plasma AT Ⅰ was lower than that in control; the control group was (2.39±1.05) μg·L -1 , AACG was (1.19±1 02) μg·L -1 ( P <0.05). CONCLUSION Change of plasma cardionatrin in primary glaucoma may be related with its pathogensis. Whether there is a relationship among AT, ALD, cardionatrin as well as glaucoma remains to be explored.