唾液酸衍生物的合成进展

Progress in the Synthesis of Sialic Acid Derivatives

唾液酸是一类九碳糖,主要以糖脂或者糖蛋白的形式广泛分布于哺乳动物组织中,是脊椎动物细胞表面最重要的单糖.唾液酸可修饰的位点较多,目前已发展出成千上万的非天然唾液酸衍生物用于分子成像.尽管如此,非天然糖代谢工程方法还处于发展的初期,很多方面亟待发展和完善.结合本课题组的研究成果,着重介绍了唾液酸衍生物的合成进展.

Sialic acids, a family of more than 50 members of a-keto acidic monosaccharides with a 9-carbon backbone, are widely distributed in mammalian organisms in the form of glycolipids or glycoproteins. It is the most important monosaccha- ride appeared on the surface of cells of vertebrates. Nowadays, thousands of unnatural sialic acid derivatives have been syn- thesized for molecular imaging due to various modifiable sites in the sialic acid structure. However, metabolic oligosaccharide engineering （MOE）, is still locating at its preliminary stage and requiring perfection urgently. Here, the research progress in the synthesis of sialic acid derivatives is reviewed.