烯基溴化合物的合成方法研究进展

Research Advances in the Synthetic Methods of Vinyl Bromides

以烯基溴化合物为代表的烯基卤代烃(1-卤代-1-烯烃)是过渡金属催化下通过C—C偶联反应构建多取代烯烃的重要合成砌块.因此,开发简便、有效的合成烯基溴化合物的新方法越来越受到人们的重视和关注.对按照所使用的合成原料进行分类,对近年来所报道的烯基溴化合物的合成方法进行了回顾.所综述的主要的合成方法中所涉及的合成原料涵盖了酮类、炔类、炔丙醇类、烯基三氟甲磺酸酯类、3-芳基-2,3-二溴丙酸、苄基溴类、丙烯酸类、环丙烯类和烯丙醇类衍生物等共9类化合物.

Vinyl halides （1-halo-l-alkenes）, especially vinyl bromides, represent a kind of organic synthetic blocks, which play important roles in the construction of polysubstituted alkenes through transition metal-catalyzed C--C cross-coupling reactions. Consequently, there have been much attentions in facile, efficient methods of preparing vinyl bromides. According to the types of the synthetic substrates used in the literatures, newly reported means on the synthesis of vinyl bromides in re- cent years are surveyed. The synthetic substrates involved in these new approaches include ketones, alkynes, propargylic al- cohols, vinyl triflates, 3-aryl-2,3-dibromopropionic acids, benzyl bromides, acrylic acids, cyclopropenes and allylic alcohol derivatives, etc.