Th17相关细胞因子与斑秃关系的研究

The Study on The Relationship between Cytokines Related to Th17 and Alopecia Areata

目的探讨Th17相关细胞因子与斑秃发病的关系。方法将40例斑秃患者分为活动期组20例和稳定期组20例,采用ELISA法检测患者血清中IL-17和IL-23的水平,与20例正常对照组比较,并分析IL-17和IL-23之间的相关性。结果斑秃活动期组血清IL-17水平明显高于稳定期组和正常对照组,差异有统计学意义(P<0.01),斑秃稳定期组血清IL-17水平亦明显高于正常对照组,差异有统计学意义(P<0.05);斑秃活动期组血清IL-23水平明显高于稳定期组和正常对照组,差异有统计学意义(P<0.05和P<0.01),斑秃稳定期组血清IL-23水平亦明显高于正常对照组,差异有统计学意义(P<0.05)。斑秃患者血清IL-17与IL-23水平呈正相关关系(相关系数r=0.50,P<0.01)。结论斑秃的发病可能与Th17相关细胞因子平衡失调有关,表现为Th17相关细胞因子反应亢进。

Objective To explore the relationship between cytokines related to Thl7 and Alopecia areata （AA）. Meth- ods 40 AA patients were divided into active phase group （20 patients） and stable phase group （20 patients）. Serum levels of 1L-17 and IL-23 were determined by enzyme linked immunosorbent assays （ELISA） in patients with AA, and compared with 20 normal controls. We also analyzed the correlation between IL-17 and IL-23. Results Serum levels of IL-17 were significantly higher in the active phase group than the stable phase group and the control group （ P 〈 0. O1 ）, and serum levels of IL-17 were significantly higher in the stable phase group than the control group （ P 〈 0.05 ） ; Serum levels of IL-23 were significantly higher in the active phase group than the stable phase group （ P 〈 0. 05 ） and the control group （ P 〈 0.01 ）, and serum levels of IL-23 were significantly higher in the stable phase group than the control group （ P 〈 0.05 ）. There was significant positive correlation between serum levels of IL-17 and IL-23 （ r = 0. 50, P 〈 0. 01 ）. Conclusion Cytokines related to Thl7 disturbance may are related with the occurrence of AA, characterized by Cytokines related to Thl7 hyperaction.