老年慢性心衰患者ACC/AHA分期与尿酸水平关系探讨

Relationship Between Different ACC /AHA Stages and Uric Acid Levels in Aged Patients with Heart Failure

目的研究老年慢性心衰患者ACC/AHA分期与心功能指标及尿酸(UA)水平的关系。方法回顾性分析老年慢性心力衰竭患者234例,按ACC/AHA心衰进展分为A、B、C、D四组,健康体检60例作为对照组,比较各组UA水平以及左心室舒张末期内径(LVEDD)和左心室射血分数(LVEF)。结果心衰患者血UA浓度较对照组显著升高(P<0.001);其水平在心衰各亚组随心衰进展分期不同有统计学差异(P<0.05或<0.01);相关分析表明,不同心衰分期的患者UA与LVEF呈负相关(r=-0.236,P<0.05),与LVEDD呈正相关(r=0.362,P<0.05)。结论血尿酸水平随着心衰进展分期的增加而升高,与LVEF呈负相关,LVEDD呈正相关,能较好地反映慢性心力衰竭患者的不同心衰分期状态,可应用于临床评价心功能。

Objective To study the relationship between different ACC/AHA stages and uric acid levels in aged patients with heart failure. Methods A retrospective analysis of 234 cases senile patients with chronic heart failure, is divided into A, B, C, D four groups of healthy physical examination with 60 cases as control group. The comparison between groups of blood UA lev- els and left ventricular end-diastolic diameter （LVEDD） and left ventricular ejection fraction （LVEF）. Results Heart failure pa- tients blood UA concentrations were significantly higher than the control group（ P 〈 0. 001 ）. Its level in each subgroup with heart disease heart failure degree aggravating and elevated significantly （P 〈0. 05 or 0. 01 ） ;Correlation analysis showed that the cardiac function in different stage of senile heart failure patients with UA and LVEF showed a negative correlation （ r = - 0. 236, P 〈 0. 05 ）, and LVEDD were positively correlated （ r = 0. 362, P 〈 0. 05 ）. Conclusion Serum uric acid levels increased with the increase of heart failure development stages, and negative correlation with LVEF value, positively correlated with LVEDD and can well reflect heart function, can be applied to the clinical evaluation of cardiac function.