非遗传因素(年龄、性别)对肾移植患者他克莫司药物浓度影响的研究

Effects of Nongenetic Factors(Age and Gender) on Tacrolimus Blood Concentrations in Renal Transplant Recipients

目的探讨肾移植患者接受他克莫司(FK506)治疗后药物浓度与年龄、性别的关系。方法应用全自动化学发光免疫分析仪器测定不同年龄、性别的86例(804例次)患者在肾移植术后口服FK506后的血药浓度。结果年龄<45岁和≥45岁的女性患者术后第2个月时FK506的血药浓度分别为(9.68±1.21)和(10.55±0.77)μg·L-1;术后>3个月时FK506的血药浓度分别为(5.13±1.54)和(5.19±1.57)μg·L-1。年龄<45和≥45年龄男性患者术后第2个月时FK506的药物浓度分别为(10.03±2.13)和(11.17±3.92)μg·L-1;术后>3个月时FK506的药物浓度分别为(4.94±1.75)和(5.03±1.83)μg·L-1。随着年龄增大,FK506的血药浓度也有所增高,但差异无统计学意义(均P>0.05);不同性别的患者对FK506的血药浓度均不产生影响。结论肾移植术后男性及女性不同年龄各时间段的FK506全血浓度分析发现,随着年龄的增大,血药浓度亦有所增高;不同性别对FK506的血药浓度均不产生影响。

Objective To investigate the relationships between tacrolimus （FK506） blood concen- trations and nongenetic factors （age and gender） in renal transplant recipients. Methods FK506 blood concentrations were determined using automated chemiluminescence immunoassay system in 86 renal transplant recipients of different ages and gender （804 examinations）. Results FK506 blood concentr- ations in female patients less than 45 years of age and female patients 45 years of age or older were, respectively, （9.68±1.21） μg.L-1 and （10.55±0.77） μg.L-1 during the second month after operation, and （5.13_±1.54） μg.L-1 and （5.19±1.57）μg.L-1 more than 3 months after operation. FK506 blood concentrations in male patients less than 45 years of age and male patients 45 years of age or older were, respectively, （10.03 ±2.13） μg .L-1 and （11.17 ±3.92） μg .L-1 during the second month after operation, and （4.94±1.75） μg.L-1 and （5.03±1.83） μg.L-1 more than 3 months after operation. FKS06 blood concentrations increased with age, but differences were not significant among patients of different ages （P〉0.05）. No correlation was found between gender and FK506 blood concentrations. Conclusion FK506 blood concentrations are positively correlated with age,but not correlated with gender in renal transplant recipients.