吗氯贝胺治疗抑郁症

Moclobemide in treating depression

目的 :比较吗氯贝胺和丙米嗪治疗抑郁症的疗效及不良反应。方法 :10 7例抑郁症分成 3组。吗氯贝胺双盲组 (吗氯贝胺组 ) 2 5例 (男性 16例 ,女性 9例 ;年龄 36a±s 10a) ,予吗氯贝胺 2 0 0mg ,po ,bid。丙米嗪双盲组 (丙米嗪组 ) 2 6例 (男性 14例 ,女性 12例 ;年龄 36a± 12a) ,予丙米嗪 10 0mg ,po ,bid。吗氯贝胺开放组 (开放组 ) 56例 (男性 2 7例 ,女性 2 9例 ;年龄 39a± 13a)予吗氯贝胺 2 0 0mg ,po ,bid ;均 4wk为一个疗程。结果 :吗氯贝胺组有效率 96% ,丙米嗪组 96% ,Ridit分析P >0 .0 5,开放组 95%。药物不良反应发生率丙米嗪组高于吗氯贝胺组。结论 :吗氯贝胺与丙米嗪治疗抑郁症疗效相同 。

AIM: To compare the efficacy and adverse reactions of moclobemide and imipramine in treating depression. METHODS: One hundred and seven patients with depression were randomly divided into 3 groups: in a double blind study, moclobemide group of 25 patients (M 16, F 9; age 36 a±s 10 a) was treated with moclobemide, 200 mg, po , bid; imipramine group of 26 patients (M 14, F 12; age 36 a±12 a) was treated with imipramine, 100 mg, po , bid; another 56 patients as open group (M 27, F 19; age 39 a±13 a) were treated with moclobemide, 100 mg, po , bid, all for 4 wk. RESULTS: The clinical effective rates of both the moclobemide and imipramine groups were 96% ( P > 0.05 ), that of open group were 95%. The adverse reactions in imipramine group were higher than in moclobemide group. CONCLUSION: Moclobemide shows the similar effects to imipramine, but the adverse reactions of the former are less than that of the latter.