摘要
目的探讨N末端脑钠肽前体(NT-proBNP)位于灰色区域对老年急性呼吸困难患者的临床诊断价值。方法选取2009年8月—2012年11月以急性呼吸困难为主要症状就诊于本院急诊及住院的患者389例,将诊断为左室射血分数保留的心力衰竭(HFPEF)所致的呼吸困难患者60例作为HFPEF组,将诊断为肺源性呼吸困难患者40例作为肺源性呼吸困难组。测定两组患者血浆NT-proBNP水平,采用超声心动图仪测定左心房内径(LAD)、左心室舒张末内径(LVDd)、室间隔舒张末厚度(IVST)、左室后壁舒张末厚度(LVPWT)、左室射血分数(LVEF),计算左心房内径指数(LADI)及左室质量指数(LVMI)。结果两组患者LADI、LVDd、LVEF及治疗前NT-proBNP比较,差异均无统计学意义(P>O.05);HFPEF组患者LVMI高于肺源性呼吸困难组,治疗1周后NT-proBNP水平低于肺源性呼吸困难组(P<0.05)。结论血浆NT-proBNP水平结合LVMI对NT-proBNP处于灰色区域的HFPEF的诊断有重要参考价值。
Objective To investigate the clinical value of N - terminal Pro - brain natriuretic peptide （ NT - proBNP） in grey area in diagnosis of elderly emergency patients with dyspnea. Methods 389 patients with acute respiratory distress ad- mitted to our hospital from August 2009 to November 2012 were divided into HFPEF group （60 cases） and pulmonary dyspnea group （40 cases） by diagnostic results. The plasma NT -proBNP were determined, and left atrium diameter （LAD） , left ven- tricular end- diastolic diameter （LVDd）, interventricular septum thickness （IVST）, left ventricular posterior wall thickness （LVPWT） , left ventrieular ejection fraction （LVEF） , LADI and LVMI were measured by doppler ultrasound cardiograph. Re- sults LADI, LVDd, LVEF and beginning NT - proBNP between two groups showed no statistically significant differences （ P 〉 0. 05） . The LVMI in HFPEF group was higher than that of pulmonary dyspnea group, after 1 week treatment, the level of NT - proBNP was lower than that of pulmonary dyspnea group （ P 〈 0.05 ）. Conclusion NT - proBNP combined with LVMI has important reference value to diagnosis of HFPEF.
出处
《实用心脑肺血管病杂志》
2014年第4期88-89,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
