COPD患者血清肺表面活性物质蛋白D与炎性标记物的相关性

Correlation of surfactant protein D with inflammatory markers in patients with chronic obstructive pulmonary disease

目的探讨肺表面活性物质蛋白D(SP-D)在AECOPD中的临床意义及与降钙素原(PCT)、C-反应蛋白(CRP)的相关性。方法选取AECOPD患者40例为实验组,30例健康人为对照组。采用酶联免疫吸附法测定治疗前、治疗第15天及健康人血清SP-D、PCT及CRP水平。结果 AECOPD组治疗前、治疗后血清SP-D、PCT、CRP水平均显著高于正常对照组,且治疗后SP-D、PCT及CRP水平均低于治疗前;AECOPD治疗前血清SP-D与PCT水平呈正相关(r=0.418);SP-D与CRP无相关性。结论 (1)SP-D可能是反映COPD急性加重的一个指标。(2)AECOPD治疗前血清SP-D水平与PCT水平呈正相关,与CRP无相关性。

Objective To explore the clinical significance of surfactant protein D （SP-D） in acute exacerbation of chronic obstructive pulmonary disease and the correlation of SP-D with procalcitonin and C-reactive protein.Methods 40 patients with AECOPD and 30 healthy people were enrolled.Venous samples from the healthy people and the patients with AECOPD in the first day and the 15th day were obtained to detect the serum levels of SP-D,PCT and CRP respectively by enzyme linked immunosorbent assay （ELISA） method.Results The levels of serum SP-D,PCT and CRP in patients with AECOPD before and after therapy were significantly higher than those of the healthy individuals.Two weeks after therapy,the levels of SP-D,PCT and CRP were lower than the first day.The levels of serum SP-D in patients with AECOPD before therapy was positively correlated with PCT （r =0.418）,but it had no correlation with CRP.Conclusion 1.SP-D may be a marker which can reflect COPD with acute exacerbation.2.The serum level of SP-D in patients with AECOPD before therapy is positively correlated with PCT,but it has no correlation with CRP.