原发性高血压病患者脑小血管病与尿微量清蛋白的关系研究

Relationship between Cerebral Small Vessel Disease and Microalbuminuria in Essential Hypertension Patients

目的探讨原发性高血压病患者脑小血管病(SVD)与尿微量清蛋白(MAU)的关系。方法选择2008年1月—2012年12月厦门大学附属中山医院住院及门诊诊断为原发性高血压病的患者100例,根据颅脑磁共振成像(MRI)检查结果,分为SVD阳性组和SVD阴性组,详细记录两组的临床资料,包括年龄、性别、体质指数、收缩压、舒张压、脉压、空腹血糖、总胆固醇、三酰甘油、肌酐、MAU水平,采用单因素和多因素Logistic回归法分析原发性高血压病患者SVD的影响因素。结果 SVD阳性组与SVD阴性组患者性别、体质指数、舒张压、空腹血糖、总胆固醇、三酰甘油、肌酐水平比较,差异均无统计学意义(P>0.05);而年龄、收缩压、脉压、MAU比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,年龄、收缩压、MAU与原发性高血压病患者SVD有回归关系(P<0.05)。结论年龄、收缩压、MAU为原发性高血压病患者SVD发病的独立危险因素,提示原发性高血压病患者SVD与早期肾损害有相关性。

Objective To explore the relationship between cerebral small vessel disease （SVD） and microalbuminuria in essential hypertension patients. Methods A total of 100 essential hypertensive patients who were diagnosed in inpatient and outpatient department of Zhongshan Hospital Affiliated to Xiamen University from January 2008 to December 2012, were divided into SVD - positive group and SVD - negative group according to MRI. Clinical data of the two groups, such as age, sex, body mass index, systolic blood pressure, diastolic blood pressure, pulse blood pressure, fasting plasma glucose, total cholesterol, triglycerides, creatinine and microalbuminuria were recorded, and influence factors of SVD among essential hypertensive patients were analyzed by single factor analysis and multiple Logistic regression. Results There were no significant differences in sex, body mass index, diastolic blood pressure, fasting plasma glucose, total cholesterol, triglycerides and creatinine between SVD - positive group and SVD - negative group （ P 〉 0. 05 ） . There were significant differences in age, systolic boold pressure, pulse blood pressure and microalbuminuria between two groups （ P 〈 0. 05 ） . According to multiple Logistic regression analysis result, the age, systolic boold pressure and mieroalbuminuria were associated with the occurrence of SVD （ P 〈 0. 05 ）. Conclu- sion The age, systolic boold pressure and microalbuminuria were independent risk factors for SVD, which indicated that there was some correlation between SVD and early renal damage in essential hypertensive patients.