不同维生素D制剂对育龄女性血清甲状旁腺激素及总抗氧化能力的影响

Effects of Different Dosage Forms of Vitamin D on Serum PTH and T-AOC of Women at Reproductive Age

目的探讨不同维生素D(VitD)制剂对育龄女性血清甲状旁腺激素(PTH)、总抗氧化能力(T-AOC)的影响。方法选择2012年9―10月成都大学附属医院体检科体检健康未绝经女性78例,采用计算机随机数字表法分为两组:VitD2组38例,口服药组40例。VitD2组予以VitD2注射液肌肉注射,每两周注射40万U;口服药组予以口服碳酸钙D3片+多维元素片各1片/d,干预时间均为8周。干预前后分别测定血清PTH、T-AOC水平。结果干预前,VitD2组与口服药组血清PTH〔(28.22±11.98)ng/L与(28.05±13.20)ng/L〕和T-AOC〔(22.69±5.26)U/ml与(23.56±5.24)U/ml〕比较,差异均无统计学意义(P>0.05);干预后,VitD2组较口服药组血清PTH〔(22.97±8.94)ng/L与(29.30±10.84)ng/L〕降低,T-AOC〔(34.03±10.58)U/ml与(23.60±6.07)U/ml〕升高(P<0.05)。结论大剂量VitD2注射液可以抑制育龄女性血清PTH水平,提高血清T-AOC水平,改善机体的氧化应激状态。

Objective To explore the effects of different dosage forms of vitamin D on serum PTH and T - AOC of women at reproductive age. Methods 78 healthy premenopausal women admitted to the Affiliated Hospital of Chengdu University from September to October in 2012 were randomly divided into VitD2 group （38 cases） and oral group （40 cases） . The VitD2 group was given vitamin I）2 injection by 400 000 U once every two weeks, while the oral group was given one calcium carbonate D3 tablet and multivitamin and minerals tablet respectively every day. Both groups were treated for eight weeks. The serum PTH and T - AOC were measured before and after the treatment. Results Before intervention, the serum PTH [ （28.22 ± 11.98） ng/Lvs. （28.05±13.20） ng/L] andT-AOC [ （22.69±5.26） U/mlvs. （23.56±5.24） U/ml] in VitD2 group and o- ral group showed no statistically significant difference （ P 〉 0. 05 ） . After intervention, the serum PTH [ （22.97± 8.94） ng/ L vs. （29. 30 ±10. 84） ng/L3 was decreased and T - AOC [ （34. 03 ± 10. 58） U/ml vs. （23.60 ±6. 07） U/ml] was in- creased in VitD2 group than in oral group （ P 〈 0.05） . Conclusion Megadose of vitamin D can reduce the level of serum PTH of women at reproductive age and increase the level of T - AOC, thus improving the oxidative stress state of the body.