高渗盐水对结直肠癌术后早期炎性肠梗阻患者胃肠功能的影响

Effect of 5% Hypertonic Saline on Early Postoperative Inflammatory Small Bowel Obstruction after Operation for Colorectal Cancer

目的探讨高渗盐水对结直肠癌术后早期炎性肠梗阻患者胃肠功能的影响。方法选取2005年9月—2009年6月漯河医学高等专科学校第二附属医院普通外科术后出现小肠梗阻的结直肠癌患者30例为对照组,2009年7月—2012年12月术后出现小肠梗阻的结直肠癌患者32例为试验组,对照组患者术后采用传统治疗方法,给以胃肠减压、应用生长抑素并按生理需要量补充液体;试验组患者在对照组基础上加用5%氯化钠溶液(4 ml/kg),两组均治疗7 d。比较两组患者腹痛缓解时间、腹胀缓解时间、排气时间、排便时间、胃管停留时间、重置胃管率。结果治疗7d,试验组患者较对照组腹痛缓解时间〔(2.0±0.1)d与(3.6±1.3)d〕、腹胀缓解时间〔(3.2±1.0)d与(5.7±1.7)d〕、排气时间〔(2.0±1.2)d与(4.1±2.1)d〕、排便时间〔(3.8±1.6)d与(6.4±2.5)d〕、胃管停留时间〔(4.1±2.1)d与(8.2±2.2)d〕缩短,重置胃管率〔1.2%(4/32)与26.7%(8/30)〕减少(P<0.05)。结论高渗盐水可以促进结直肠癌术后早期炎性肠梗阻患者胃肠功能恢复。

Objective To explore the effect of 5 % hypertonic saline （HS） on early postoperative inflammatory bowel obstruction （EPIBO） of patients with coloreetal cancer after operation. Methods 30 patients occurring small bowel obstruction after operation for coloreetal cancer in the General Surgery of the Second Affiliated Hospital of Luohe Medical College from Sep- tember 2005 to June 2009 were selected as the control group, while 32 such patients from July 2009 to December 2012 were se- lected as the experimental group. The control group was given conventional treatment such as gastroenteric decompression, soma- tostatin and fluid supplementation. The experimental group was given additional 5% HS （4 mg/kg） . The abdominal pain relief time, abdominal distension relief time, intestinal exhausting time, diaehoresis time, stomach tube retain time and stomach tube replacement were compared between the two groups. Results After 7 d treatment, the abdominal pain relief time [ （2. 0 ± 0. 1 ） d vs. （3.6 ± 1.3 ） d 3, abdominal distension relief time [ （ 3.2 ± 1.0） d vs. （ 5.7 ± 1.7 ） d 3, intestinal exhausting time [ （2. 0 ± 1.2） d vs. （4. 1 ±2. 1 ） d3, diachoresis time [ （3.8± 1.6） d vs. （6. 4 ±2. 5） d], stomach tube retain time [ （4. 1 ± 2. 1 ） d vs. （8.2 ± 2. 2 ） d] and stomach tube replacement [ 1.2% （4/32） vs. 26. 7% （8/30） ] all showed statistically sig- nificant differences between the two groups （P 〈 0. 05 ） . Conclusion 5% HS can promote gastrointestinal function of patients with EPIBO after operation for eoloreetal cancer.