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CREB与阿片类药物依赖 被引量:3

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摘要 CREB是亮氨酸拉链转录因子 ,阿片类药物依赖产生后 CREB的表达和磷酸化水平发生改变 ,并作用于 c AMP信号传导通路中的某些成分 ,影响戒断症状的产生。 CREB还与长时记忆和精神依赖的形成有关。
出处 《国外医学(精神病学分册)》 2001年第1期47-49,共3页 Foreign Medical Sciences(Section of Psychiatry)
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参考文献10

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同被引文献24

  • 1Boening J A. Neurobiology of an addiction memory. J Neural Transm, 2001, 108(6):755-765
  • 2Berke J D,Hyman S E.Addiction,dopamine, and the molecular mechanisms of memory .Neuron, 2000, 25:515-532
  • 3Nestler E J. Total recall-the memory of addiction.Science, 2001,292:2266-2267
  • 4De Vries T J, Shippenberg T S. Neural System Underlying Opiate Addiction. Neurosci, 2002,22(9):3321-3325
  • 5Leshner A I. Addiction is a brain disease, and it matters.Science, 1997, 278(5335):45-47
  • 6Wang HR, Gao XR, Han Ji-Sheng. et al. DD-PCR and DNA microarray analysis of gene ex pression of acute and chronic morphine dependent neural cells. Chinese J Neurosci, 2001, Supplement
  • 7Helmuth L. Beyond the Pleasure Principle. Science, 2001,294:983-984
  • 8Nestler E J, Aghajanian G K. Moleular and Cellular Basis of Addiction .Science, 1997, 278:58-63
  • 9Lu Pu, Guo-Bin Bao,Nan-Jie Xu et al. Hippcampal Long-Term Poteniation is Reduced by Chronic Opiate Treatment and Can be Restored by Re-exposure to Opiates. Neurosci, 2002, 22(5): 1914-1921
  • 10Heyyne A, May T, Goll P, et al. Persisting consequences of drug intake :toward a memory of addiction . J Neural Transm, 2000, 107(6):613-638

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