瘤体内注射卡铂和消痔灵对荷瘤鼠的抗肿瘤作用及其毒性

The antitumor effects and toxicity of carboplatin and Xiaozhiling administered intratumorally in mice with tumor

目的 :观察瘤内注射 (it)卡铂 (CBP)和消痔灵 (XZL)的抗肿瘤作用。方法 :选用小鼠S180 实体瘤模型 ,itXZL、it及静脉注射 (iv)CBP治疗 ,测定各组小鼠的瘤重、体重、脾指数和胸腺指数。结果 :与生理盐水 (NS)组比较 ,ivCBP 30mg/kg、itXZL 10ml/kg和itCBP 30、6 0mg/kg的抑瘤率分别为 2 0 .2 3% ,2 5 .6 % ,2 7.4%和 41.9% ,脾指数变化分别为 - 41.0 % ,13.2 % ,- 2 8.4%和 - 49.2 % ,胸腺指数变化分别为 - 8.5 % ,33.0 % ,- 5 .3%和 - 12 .8%。结论 :itCBP和XZL均有抗肿瘤作用。CBP降低荷瘤鼠免疫器官指数 ,而XZL则增加荷瘤鼠免疫器官指数。

OBJECTIVE:To observe the antitumor effects and toxic reaction of carboplatin and Xiaozhiling after intratumor administration in mice with solid S 180 tumor.METHODS:30 and 60 mg/kg carboplatin to 10 ml/kg xiaozhiling were administered intratumorally and 30mg/kg carboplatin intravenously every three day for one week in mice with transplanted tumor.The weights of tumor and body,the index of spleen and thymusgland were measured.RESULTS:Compared with normal saline group,the growth of tumor in 30,60 mg/kg carboplatin treated and 10 ml/kg xiaozhiling groups was all inhibited,with inhibitory rates of 27.4%,41.9% and 25.6%,respectively.The indexes of spleen were decreased by 38.6% and 49.8%,and thymusgland 4.9% and 14.2% in mice treated with 30 and 60 mg/kg carboplatin,while the indexes of spleen and thymusgland in mice treated with Xiaozhiling were increased by 13.2% and 33.5%,respectively.The average mouse weights had no significant difference in every group.CONCLUSION:Carboplatin and xiaozhiling showed significant antitumor effects when injected intratumorally.The indexes of immune organs was decreased by carboplatin,while increased by Xiaozhiling.