氯屈膦酸二钠合成工艺改进

Improved synthesis of clodronate

目的 :对氯屈膦酸二钠的合成工艺进行了研究。方法 :以二溴甲烷和亚膦酸三异丙酯为原料 ,经缩合、氯化、热裂解和成盐反应得到氯屈膦酸二钠。结果 :合成产物的化学结构经元素分析、红外光谱、质谱和核磁共振谱确证 ,总收率为 6 0 .3%。结论 :此合成路线是完全可行的。

OBJECTIVE:To study the synthesis of clodronate.METHODS:Clodronate was synthesized by steps of condensation,chloration,pyrolysis and salifying from dibromomethane and triisopropyl phosphite.RESULTS:The chemical structure of synthetic product was confirmed by element analysis,IR,MS,and 31 PNMR.CONCLUSION:This synthetic route is practical.