非水溶性软膏供试液制备方法的探讨

Sludy of the method to prepare the test preparation of ointment insoluble in water

目的 :探讨简便、快速制备非水溶性软膏供试液的方法。方法 :采用十四烷酸异丙酯溶介非水溶性基质 ,再以吐温 80为乳化剂制备供试液。结果 :上述方法所制备的溶液乳化均匀 ,与药典法比较 ,其结果一致。结论 :本法简便、快速、可靠 ,不失为一种较为理想且实用的方法。

OBJECTIVE:To establish a simple and rapid method which was used to prepare the test preparation of ointment insoluble in water.METHOD:Ointment bases first was firstly disolved with isopropyl myristate and then the test preparation was prepared with polysorbate 80 as emulsifier.RESULTS:The emulsion obtained as described above was homogeneous and the result was correspondent to the CP method.CONCLUSION:This method was simple,rapid,reliable and practical.